Cerebellar amyloid-β plaques: disturbed cortical circuitry in AβPP/PS1 transgenic mice as a model of familial Alzheimer's disease

Journal of Alzheimer's Disease : JAD
Selene LomoioIsidro Ferrer

Abstract

Cerebellar amyloid-β (Aβ) deposition in the form of neuritic plaques and Purkinje cell loss are common in certain pedigrees of familial Alzheimer's disease (FAD) mainly linked to PS1 mutations. AβPP/PS1 transgenic mice, here used as a model of FAD, show a few Aβ plaques in the molecular layer of the cerebellum at 6 months, and which increase in number with age. Motor impairment is apparent in transgenic mice aged 12 months. Combined methods have shown degenerated parallel fibers as the main component of dystrophic neurites of Aβ plaques, loss of synaptic contacts between parallel fibers and dendritic spines of Purkinje cells, and degeneration of granule cells starting at 12 months and increasing in mice 18/20 months old. In addition, abnormal mitochondria and focal loss of Purkinje and basket cells, together with occasional axonal torpedoes and increased collaterals of Purkinje cells in mice aged 18/20 months, is suggested to be a concomitant defect presumably related to soluble extracellular or intracellular Aβ. These observations demonstrate serious deterioration of the neuronal circuitry in the cerebellum of AβPP/PS1 transgenic mice, and they provide support for the interpretation of similar alterations occurring in certain ...Continue Reading

Citations

Sep 7, 2013·Experimental & Molecular Medicine·Arulmani ManavalanKlaus Heese
Jun 21, 2019·The Cerebellum·Ana Paula Bergamo AraujoFlávia Carvalho Alcantara Gomes
Oct 21, 2017·Brain : a Journal of Neurology·Heidi I L JacobsJeremy D Schmahmann
Aug 29, 2016·Journal of Alzheimer's Disease : JAD·Lara Ordoñez-GutierrezFrancisco Wandosell
Dec 14, 2018·Frontiers in Aging Neuroscience·Eriola HoxhaMaria Concetta Miniaci
Nov 21, 2017·Journal of Alzheimer's Disease : JAD·Isidro Ferrer
Jul 28, 2020·Neurochemistry International·Pranav Kumar VemulaPing Liu

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