Cerebellar and cerebral autoregulation in migraine

Stroke; a Journal of Cerebral Circulation
Matthias ReinhardHolger Kaube

Abstract

Silent ischemic brain lesions frequently occur in migraine with aura and are most often located in cerebellar border zones. This may imply an impairment of cerebellar blood flow autoregulation. This study investigated the characteristics of interictal cerebellar autoregulation in migraine with and without aura. Thirty-four patients (n=17, migraine without aura; n=17, migraine with aura) and 35 age- and sex-matched controls were studied. Triple simultaneous transcranial Doppler monitoring of one posterior inferior cerebellar artery, right posterior cerebral artery, and left middle cerebral artery was performed. Autoregulation dynamics were assessed from spontaneous blood pressure fluctuations (correlation coefficient index Dx) and from respiratory-induced 0.1-Hz blood pressure oscillations (phase and gain). Compared with controls, the autoregulatory index Dx was higher (indicating less autoregulation) in the posterior inferior cerebellar artery (P=0.0062) and middle cerebral artery (P=0.0078) in migraine with aura, but not in migraine without aura. Phase and gain did not significantly differ between migraine patients and controls. No significant associations of autoregulation with clinical factors were found, including frequency...Continue Reading

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Citations

Oct 9, 2013·Hypertension·Wibke G JanzarikMatthias Reinhard
Sep 22, 2012·Stroke; a Journal of Cerebral Circulation·Tobias Kurth, Hans-Christoph Diener
Oct 10, 2018·Cephalalgia : an International Journal of Headache·Cédric GollionVincent Larrue
Sep 29, 2019·Headache·Maria J KnolM Arfan Ikram
Apr 18, 2018·BioMed Research International·Nai-Fang ChiHan-Hwa Hu
Feb 11, 2020·The Journal of Physiological Sciences : JPS·Takuro WashioShigehiko Ogoh
Oct 23, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jemima Sa DzatorRachel Hx Wong
May 8, 2021·Frontiers in Human Neuroscience·Claudia AltamuraGianluca Coppola
May 15, 2020·Journal of the Neurological Sciences·Raffaele OrnelloSimona Sacco
Nov 24, 2021·Stroke; a Journal of Cerebral Circulation·Sigurdur SigurdssonLenore J Launer

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