Cerebellar and extracerebellar involvement in mouse eyeblink conditioning: the ACDC model.

Frontiers in Cellular Neuroscience
Henk-Jan BoeleChris I De Zeeuw

Abstract

Over the past decade the advent of mouse transgenics has generated new perspectives on the study of cerebellar molecular mechanisms that are essential for eyeblink conditioning. However, it also appears that results from eyeblink conditioning experiments done in mice differ in some aspects from results previously obtained in other mammals. In this review article we will, based on studies using (cell-specific) mouse mutants and region-specific lesions, re-examine the general eyeblink behavior in mice and the neuro-anatomical circuits that might contribute to the different peaks in the conditioned eyeblink trace. We conclude that the learning process in mice has at least two stages: An early stage, which includes short-latency responses that are at least partly controlled by extracerebellar structures such as the amygdala, and a later stage, which is represented by well-timed conditioned responses that are mainly controlled by the pontocerebellar and olivocerebellar systems. We refer to this overall concept as the Amygdala-Cerebellum-Dynamic-Conditioning Model (ACDC model).

Citations

Sep 22, 2011·Behavioural Brain Research·Andrew J CarrelVlastislav Bracha
Jul 26, 2015·Neurobiology of Learning and Memory·Chen HuBo Hu
Oct 1, 2010·The European Journal of Neuroscience·Toshiro Sakamoto, Shogo Endo
Aug 21, 2014·Brain Structure & Function·María Fernanda Vinueza VelozChris I De Zeeuw
Jul 15, 2015·ELife·Alexander D KlothSamuel S-H Wang
Apr 18, 2018·Nature Neuroscience·Catarina AlbergariaMegan R Carey
Aug 17, 2012·Nature Reviews. Neuroscience·Zhenyu GaoChris I De Zeeuw
May 6, 2011·Nature Reviews. Neuroscience·Chris I De ZeeuwSebastiaan K Koekkoek
Jul 4, 2020·International Journal of Neural Systems·Daniele Caligiore, Pierandrea Mirino
Aug 17, 2012·Journal of Neurophysiology·John S Stahl, Zachary C Thumser
Dec 17, 2020·Journal of Neurophysiology·Nina L de OudeHenk-Jan Boele
Feb 19, 2021·The Journal of Comparative Neurology·Paul J May, Susan Warren
Jul 2, 2021·Frontiers in Neural Circuits·Moritoshi HironoYuchio Yanagawa
Jul 17, 2021·Frontiers in Behavioral Neuroscience·Henk-Jan BoeleRyan N Dilger

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Methods Mentioned

BETA
transgenics
chips
transgenic

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