Cerebellar and striatal dopamine receptors: effects of reeler and weaver murine mutations

Journal of Neuroscience Research
N T PanagopoulosT Valcana

Abstract

The presence and the binding characteristics of D1 and D2 receptors were investigated in normal-reeler and normal-weaver mutant mice utilizing [3H]spiperone (D2 antagonist), [3H]SKF 38393 (D1 agonist), and [3H]DA as ligands. Analysis of the binding data showed that in the cerebellum there are two binding components for all [3H]ligands. Comparison of the binding constants from cerebellum and striatum showed that in cerebellum the high affinity-low capacity component has similar affinity with that of striatum. The reeler and weaver mutations affected the binding of all ligands: In reeler, total cerebellar specific binding sites for [3H]spiperone and [3H]SKF 38393 decrease significantly (approximately 50% and approximately 70%, respectively), while those for [3H]DA show a small (approximately 10-15%) but not significant decrease. In weaver, total cerebellar specific binding sites for [3H]spiperone, [3H]SKF 38393, and [3H]DA also decrease significantly (approximately 60%, approximately 70%, and approximately 50%, respectively). In reeler striatum [3H]SKF 38393 binding (Bmax) is significantly decreased (approximately 24%), while [3H]spiperone and [3H]DA binding (Bmax) is not affected. In weaver striatum, [3H]SKF 38393 binding is sig...Continue Reading

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Citations

May 28, 2013·Behavioural Brain Research·C JacquelinC Strazielle
Jul 23, 2005·The Cerebellum·Panagiotis Giompres, Foteini Delis
Jun 13, 2008·The European Journal of Neuroscience·Alasdair M BarrWilliam G Honer
Jun 8, 2007·The European Journal of Neuroscience·Hideo MatsuzakiKohji Sato
Sep 4, 2014·Frontiers in Neurology·Asha Kishore, Traian Popa
Jul 22, 2017·Autism Research : Official Journal of the International Society for Autism Research·Krishna SubramanianGene J Blatt
Mar 3, 2006·Journal of Neuroscience Research·C StrazielleR Lalonde

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