PMID: 11904042Mar 21, 2002Paper

Cerebellar aspergillosis: case report and literature review

Neurosurgery
Ersin ErdoganBülent Celasun

Abstract

An unusual, but not unique, case of cerebellar aspergillosis associated with autologous peripheral blood stem cell transplantation for breast cancer is presented. A 45-year-old woman with breast cancer underwent chemotherapy and radiotherapy as well as autologous peripheral blood stem cell transplantation. She developed a cerebellar aspergillosis abscess that was treated successfully with two surgical resections. After removal of pus and the abscess wall, the patient received local application of amphotericin B (AmB). She received AmB 1 mg/kg/d for 3 months and itraconazole 100 mg/kg/d for 1 year. After 3 months of AmB treatment, magnetic resonance imaging revealed that disease had not recurred. In cases of central nervous system aspergillosis, to increase the therapeutic efficiency, AmB can also be applied to the abscess cavity. Computed tomographic and contrast-enhanced magnetic resonance imaging scans play an important role in establishing early diagnosis in high-risk, immunocompromised patients.

References

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Citations

Jan 10, 2006·Arquivos de neuro-psiquiatria·Geraldo Pianetti FilhoRogério Darwich
Jun 12, 2012·Journal of Neurosurgery. Pediatrics·Sumit ThakarAlangar S Hegde
Jun 4, 2008·Neurosurgical Focus·Ersin Erdoğan, Tufan Cansever
Feb 24, 2007·Neurologia Medico-chirurgica·Shinya NabikaJumpei Oshita
Oct 20, 2009·Arquivos de neuro-psiquiatria·Hélio A G TeiveLineu César Wemeck
Mar 11, 2006·Neurosurgery·Sandeep MohindraKim Vaiphei
Jun 17, 2021·Annals of Clinical Microbiology and Antimicrobials·Aref ShariatiZahra Chegini
Sep 18, 2004·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·P TattevinB Régnier

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