Cerebellar aspergillosis in an infant: case report

Neurosurgery
Sandeep MohindraKim Vaiphei

Abstract

Intracranial aspergillosis is occasionally seen among immunocompromised patients, the incidence increasing in consequence to large-scale use of chemotherapy against malignancies and immunosuppression after organ transplantation. Immunocompetent patients harboring invasive intracranial fungal infections still remain an elusive diagnosis. A 7-month-old immunocompetent infant who developed and harbored cerebellar aspergillosis until 3 years of age is reported. Radical surgical resection of posterior fossa mass (aspergilloma) and parenteral administration of Amphotericin B led to a successful outcome. The differential diagnosis at both stages of presentation and the possible mode of infection are discussed according to the radiological images. Preoperative diagnosis on the basis of imaging is difficult. The pathogenesis of such an infection remains uncertain. Parenteral Amphotericin B, followed by prolonged itraconazole therapy, remains the "gold standard" modality for central nervous system fungal infections in adjunct to aggressive surgical debridement.

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Citations

Oct 25, 2011·International Journal of Medical Sciences·Sheng ChenJian-Min Zhang
Jun 12, 2012·Journal of Neurosurgery. Pediatrics·Sumit ThakarAlangar S Hegde
May 20, 2015·World Neurosurgery·Soubhagya Ranjan TripathyKalpalata Tripathy
Nov 4, 2016·World Journal of Pediatrics : WJP·Shuang ChenYu-Ping Ran
Aug 20, 2018·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Adrian CaceresMarco Luis Herrera

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Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Central Nervous System Fungal Infections

Central nervous system fungal infections are rare and typically occur in immunocompromised patients, such as those with HIV infection or transplant recipients. Discover the latest research on central nervous system fungal infections here.

Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

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