Abstract
Cerebellar abnormalities, including decreased tissue volume, have been implicated in the pathophysiology of bipolar disorder. Relatively little research has focused on blood flow in the cerebellum of patients with bipolar disorder. Furthermore, the significance of metabolic changes in the brains of psychiatric patients may be confounded by the effects of various pharmacotherapies. Having previously found differences in cerebellar blood volume in patients with bipolar disorder compared to healthy control subjects, this study examined whether some variability in the patient population may be an effect of medication. In this study, we have examined the association between medication status and cerebellar blood volume. Thirteen healthy comparison subjects and 21 bipolar patients underwent dynamic susceptibility contrast magnetic resonance imaging. Nine cerebellar regions were identified, and the absolute cerebellar blood volume data from each was compared to medication status measures. Patients on conventional antipsychotics had the lowest mean absolute blood volume measures for all cerebellar regions, whereas those on atypical antipsychotics had the highest blood volume measures. Comparison subjects had cerebellar blood volume mea...Continue Reading
References
Feb 1, 1978·Surgical Neurology·R Davis, M A Flitter
Jan 1, 1976·Journal of Neuroscience Research·R S Snider, A Maiti
Sep 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·R J DolanR S Frackowiak
May 1, 1992·The American Journal of Psychiatry·N D VolkowF Henn
Jan 1, 1987·Clinical Neurology and Neurosurgery·D NagarajaH S Narayanan
Nov 10, 1984·The Journal of Comparative Neurology·D E Haines, E Dietrichs
Feb 2, 1981·Brain Research·J A Vilensky, G W van Hoesen
Mar 1, 1996·Psychopharmacology·A SchotteJ E Leysen
Jan 1, 1997·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·L C MaasP F Renshaw
Jan 1, 1997·Biological Psychiatry·J C Soares, J J Mann
Mar 1, 1997·Biological Psychiatry·D D MillerN C Andreasen
Jun 14, 1997·Lancet·N C AndreasenR D Hichwa
Jul 4, 1997·Psychiatry Research·L E DeLisiR Grimson
Jul 1, 1997·Acta Psychiatrica Scandinavica·R ErkwohH Sass
Dec 1, 1996·NeuroImage·J M LevinP F Renshaw
May 5, 1999·Schizophrenia Research·R T LoeberD A Yurgelun-Todd
Jun 24, 1999·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·M P DelBelloK W Sax
Mar 30, 2000·The American Journal of Psychiatry·J J KimR D Hichwa
Feb 13, 2001·Biological Psychiatry·T A KetterR M Post
Citations
Apr 20, 2010·Psychopharmacology·Kamilla W MiskowiakCatherine J Harmer
Nov 1, 2002·Schizophrenia Research·E Fuller Torrey
Sep 12, 2013·Translational Psychiatry·S H FatemiP D Thuras
May 8, 2010·Psychiatry and Clinical Neurosciences·Ajay Kumar BakhlaRakesh Kumar
Aug 3, 2010·Acta Neuropsychiatrica·Fay Y WomerHilary P Blumberg
May 24, 2011·Psychiatry Research·Marcella BellaniPaolo Brambilla
Feb 10, 2011·Schizophrenia Research·S Hossein FatemiPaul D Thuras
Oct 19, 2010·Journal of Psychiatric Research·Laura Frances MartinJason R Tregellas
Feb 15, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·E Serap MonkulJair C Soares
Jul 1, 2004·Bipolar Disorders·Gin S MalhiGordon B Parker
Feb 27, 2004·The European Journal of Neuroscience·Gin S MalhiPerminder Sachdev
Oct 18, 2006·Bipolar Disorders·M Elizabeth SubletteJ John Mann
May 29, 2012·Bipolar Disorders·Benjamin N BlondHilary P Blumberg
May 29, 2012·Bipolar Disorders·Jennifer Townsend, Lori L Altshuler
Aug 23, 2005·Biological Psychiatry·Chi-Hua ChenEd Bullmore
Apr 9, 2008·Schizophrenia Research·S Hossein FatemiFrank S Menniti
Jan 7, 2015·Molecular Psychiatry·C P JohnsonJ A Wemmie
Jan 10, 2018·Bipolar Disorders·Casey P JohnsonJohn A Wemmie
Nov 20, 2008·Psychiatric Genetics·S Hossein FatemiSusanne Lee
Jan 5, 2010·Psychiatry Investigation·Kyung-Min ParkJong Doo Lee
Jun 12, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Valentina K TodorovaSvetlana V Kyosseva
Sep 8, 2020·Brain Connectivity·Sarah V ClarkJessica A Turner
Oct 1, 2009·Acta Neuropsychiatrica·Fay Y WomerHilary P Blumberg