Cerebellar blood volume in bipolar patients correlates with medication

Biological Psychiatry
R T LoeberD A Yurgelun-Todd

Abstract

Cerebellar abnormalities, including decreased tissue volume, have been implicated in the pathophysiology of bipolar disorder. Relatively little research has focused on blood flow in the cerebellum of patients with bipolar disorder. Furthermore, the significance of metabolic changes in the brains of psychiatric patients may be confounded by the effects of various pharmacotherapies. Having previously found differences in cerebellar blood volume in patients with bipolar disorder compared to healthy control subjects, this study examined whether some variability in the patient population may be an effect of medication. In this study, we have examined the association between medication status and cerebellar blood volume. Thirteen healthy comparison subjects and 21 bipolar patients underwent dynamic susceptibility contrast magnetic resonance imaging. Nine cerebellar regions were identified, and the absolute cerebellar blood volume data from each was compared to medication status measures. Patients on conventional antipsychotics had the lowest mean absolute blood volume measures for all cerebellar regions, whereas those on atypical antipsychotics had the highest blood volume measures. Comparison subjects had cerebellar blood volume mea...Continue Reading

References

Feb 1, 1978·Surgical Neurology·R Davis, M A Flitter
Jan 1, 1976·Journal of Neuroscience Research·R S Snider, A Maiti
Sep 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·R J DolanR S Frackowiak
May 1, 1992·The American Journal of Psychiatry·N D VolkowF Henn
Jan 1, 1987·Clinical Neurology and Neurosurgery·D NagarajaH S Narayanan
Feb 2, 1981·Brain Research·J A Vilensky, G W van Hoesen
Jan 1, 1997·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·L C MaasP F Renshaw
Jan 1, 1997·Biological Psychiatry·J C Soares, J J Mann
Jul 1, 1997·Acta Psychiatrica Scandinavica·R ErkwohH Sass
May 5, 1999·Schizophrenia Research·R T LoeberD A Yurgelun-Todd
Jun 24, 1999·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·M P DelBelloK W Sax
Mar 30, 2000·The American Journal of Psychiatry·J J KimR D Hichwa

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Citations

May 8, 2010·Psychiatry and Clinical Neurosciences·Ajay Kumar BakhlaRakesh Kumar
May 24, 2011·Psychiatry Research·Marcella BellaniPaolo Brambilla
Feb 10, 2011·Schizophrenia Research·S Hossein FatemiPaul D Thuras
Oct 19, 2010·Journal of Psychiatric Research·Laura Frances MartinJason R Tregellas
Feb 15, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·E Serap MonkulJair C Soares
Jul 1, 2004·Bipolar Disorders·Gin S MalhiGordon B Parker
Feb 27, 2004·The European Journal of Neuroscience·Gin S MalhiPerminder Sachdev
Oct 18, 2006·Bipolar Disorders·M Elizabeth SubletteJ John Mann
May 29, 2012·Bipolar Disorders·Jennifer Townsend, Lori L Altshuler
Apr 9, 2008·Schizophrenia Research·S Hossein FatemiFrank S Menniti
Jan 7, 2015·Molecular Psychiatry·C P JohnsonJ A Wemmie
Nov 20, 2008·Psychiatric Genetics·S Hossein FatemiSusanne Lee
Jun 12, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Valentina K TodorovaSvetlana V Kyosseva

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