Cerebellar brain inhibition in the target and surround muscles during voluntary tonic activation

The European Journal of Neuroscience
Pattamon PanyakaewMark Hallett

Abstract

Motor surround inhibition is the neural mechanism that selectively favours the contraction of target muscles and inhibits nearby muscles to prevent unwanted movements. This inhibition was previously reported at the onset of a movement, but not during a tonic contraction. Cerebellar brain inhibition (CBI) is reduced in active muscles during tonic activation; however, it has not been studied in the surround muscles. CBI was evaluated in the first dorsal interosseus (FDI) muscle as the target muscle, and the abductor digiti minimi, flexor carpi radialis and extensor carpi radialis muscles as surround muscles, during rest and tonic activation of the FDI muscle in 21 subjects. Cerebellar stimulation was performed under magnetic resonance imaging-guided neuronavigation targeting lobule VIII of the cerebellar hemisphere. Stimulus intensities for cerebellar stimulation were based on the resting motor cortex threshold (RMT) and adjusted for the depth difference between the cerebellar and motor cortices. We used 90-120% of the adjusted RMT as the conditioning stimulus intensity during rest. The intensity that generated the best CBI at rest in the FDI muscle was selected for use during tonic activation. During selective tonic activation o...Continue Reading

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Citations

Dec 26, 2018·Current Neuropharmacology·Hiroshi Mitoma, Mario Manto
Oct 3, 2018·The Cerebellum·Kim van DunMario Manto
Jan 9, 2017·Brain Structure & Function·Antonino NaroRocco Salvatore Calabrò
Sep 24, 2020·International Journal of Molecular Sciences·Pierre CabarauxHirokazu Tanaka
Oct 8, 2021·European Journal of Applied Physiology·Brodie J HandJohn G Semmler

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