Cerebellar cognitive disorder parallels cerebellar motor symptoms in Friedreich ataxia.

Annals of Clinical and Translational Neurology
Gilles NaeijeMassimo Pandolfo

Abstract

Dentate nuclei (DN) are involved in cerebellar modulation of motor and cognitive functions, whose impairment causes ataxia and cerebellar cognitive affective syndrome (CCAS). Friedreich ataxia (FRDA) disease progression relates to degeneration of the dentate nucleus and dentato-thalamic pathways, causing cerebellar ataxia. Volumetric MRI also shows mild loss in the cerebellar cortex, brainstem, and motor cortex. Cognitive deficits occur in FRDA, but their relationship with ataxia progression is not fully characterized. We found a significant positive correlation between severity of patients' ataxia and more marked CCAS as assessed with the CCAS-Scale. This relation could be related to progressive DN impairment.

References

May 13, 1998·Brain : a Journal of Neurology·J D Schmahmann, J C Sherman
Apr 13, 2005·Neurology·S H SubramonyUNKNOWN Cooperative Ataxia Group
Apr 20, 2007·Acta Neuropathologica·Arnulf H KoeppenJacques B Lamarche
Jun 4, 2011·Acta Neuropathologica·Arnulf H KoeppenJennifer A Morral
Feb 22, 2012·The Cerebellum·Antonieta NietoJose Barroso
Jan 22, 2013·Journal of Neuropathology and Experimental Neurology·Arnulf H Koeppen, Joseph E Mazurkiewicz
Aug 9, 2013·The Cerebellum·Wolfgang NachbauerMargarete Delazer
Dec 7, 2014·The Cerebellum·Oliver BaumannArseny A Sokolov
Jan 13, 2015·Journal of Neuropathology and Experimental Neurology·Arnulf H KoeppenJoseph E Mazurkiewicz
Sep 9, 2016·Annals of Clinical and Translational Neurology·Imis DoganKathrin Reetz
Jan 14, 2017·Journal of Neuropathology and Experimental Neurology·Arnulf H KoeppenPaul J Feustel
Feb 24, 2017·The Cerebellum·Louise A CorbenMartin B Delatycki
Aug 22, 2017·Neuroscience and Biobehavioral Reviews·Louisa P SelvaduraiNellie Georgiou-Karistianis
Nov 1, 2017·The Cerebellum·Sabrina SayahAlexandra Durr
Dec 6, 2017·Brain : a Journal of Neurology·Franziska HocheJeremy D Schmahmann
Jan 13, 2018·The Cerebellum·Teresa CostabileFrancesco Saccà
Jun 22, 2018·Annals of Clinical and Translational Neurology·Sirio CocozzaFrancesco Saccà
Jul 10, 2019·Nature Neuroscience·Maedbh KingJörn Diedrichsen
Jul 19, 2019·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Joel M Gottesfeld
Oct 24, 2019·Journal of Neurology·Sirio CocozzaFrancesco Saccà
Dec 4, 2019·Trends in Neurosciences·Mark J Wagner, Liqun Luo
Dec 17, 2019·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·G NaeijeX De Tiège
Dec 20, 2019·Annals of Clinical and Translational Neurology·Gilles NaeijeXavier P De Tiège
Apr 28, 2020·Neurology. Genetics·Massimo Pandolfo

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Citations

Nov 27, 2020·Human Gene Therapy·Ian H HardingMassimo Pandolfo
Jan 8, 2021·Cerebellum & Ataxias·Eleonora LauricellaFrancesco Girolamo
Mar 21, 2021·Journal of Neurology·Roderick P P W M MaasDennis J L G Schutter
May 23, 2021·Clinical Neurology and Neurosurgery·Ece Gok-DursunIsin Unal-Cevik
Jul 9, 2021·Journal of Multidisciplinary Healthcare·David R LynchKimberly Y Lin

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