Cerebellar control of saccade dynamics: contribution of the fastigial oculomotor region

Journal of Neurophysiology
Julie Quinet, Laurent Goffart

Abstract

The fastigial oculomotor region is the output by which the medioposterior cerebellum influences the generation of saccades. Recent inactivation studies reported observations suggesting an involvement in their dynamics (velocity and duration). In this work, we tested this hypothesis in the head-restrained monkey with the electrical microstimulation technique. More specifically, we studied the influence of duration, frequency, and current on the saccades elicited by fastigial stimulation and starting from a central (straight ahead) position. The results show ipsilateral or contralateral saccades whose amplitude and dynamics depend on the stimulation parameters. The duration and amplitude of their horizontal component increase with the duration of stimulation up to a maximum amplitude. Varying the stimulation frequency mostly changes their latency and the peak velocity (for contralateral saccades). Current also influences the metrics and dynamics of saccades: the horizontal amplitude and peak velocity increase with the intensity, whereas the latency decreases. The changes in peak velocity and in latency observed in contralateral saccades are not correlated. Finally, we discovered that contralateral saccades can be evoked at sites ...Continue Reading

References

Jul 15, 1977·The Journal of Comparative Neurology·R R BattonM B Carpenter
Nov 1, 1977·Archives of Otolaryngology·B CogdellJ Kimm
Jun 1, 1976·Brain : a Journal of Neurology·D S ZeeW K Engel
Jun 1, 1991·Journal of Neurophysiology·U BüttnerP Buckmaster
Jan 1, 1990·Cold Spring Harbor Symposia on Quantitative Biology·D L SparksW H Rohrer
Nov 8, 1987·The Journal of Comparative Neurology·J Yamada, H Noda
Aug 1, 1987·Journal of Neurophysiology·D L SparksJ D Porter
Jul 15, 1986·The Journal of Comparative Neurology·A StrassmanR A McCrea
Jul 15, 1986·The Journal of Comparative Neurology·A StrassmanR A McCrea
Nov 1, 1973·Journal of Neurophysiology·S Ron, D A Robinson
Aug 1, 1971·Experimental Neurology·J C Aschoff, B Cohen
Jan 1, 1970·Experimental Brain Research·M ItoM Udo
Dec 1, 1984·Experimental Neurology·J G McElligott, E L Keller
Jun 1, 1984·Brain : a Journal of Neurology·V HennH Reisine
Jan 1, 1984·Experimental Brain Research·F BenedettiS Rabacchi
Mar 1, 1981·Journal of Neurophysiology·J A Van GisbergenS Gielen
Dec 1, 1980·Journal of Neurophysiology·L M Optican, D A Robinson
Oct 17, 1998·Journal of Neurophysiology·M TakagiR J Tamargo
Jan 1, 2000·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·P D Gamlin
Sep 9, 2000·Journal of Neurophysiology·E L KellerT Salz

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Citations

Sep 15, 2017·Journal of Neurophysiology·Laurent GoffartNeeraj J Gandhi
Jul 12, 2018·Journal of Neurophysiology·Clara BourrellyLaurent Goffart
Nov 1, 2018·Journal of Neurophysiology·Laurent GoffartJean-Charles Quinton
Jul 24, 2015·Journal of Neurophysiology·Andrew B WolfGidon Felsen
Apr 12, 2018·Journal of Neurophysiology·Clara BourrellyLaurent Goffart

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