Cerebellar control of the inferior olive

The Cerebellum
Fredrik Bengtsson, Germund Hesslow

Abstract

A subpopulation of neurones in the cerebellar nuclei projects to the inferior olive, the source of the climbing fibre input to the cerebellum. This nucleo-olivary projection follows the zonal and, probably also, the microzonal arrangement of the cerebellum so that closed loops are formed between the neurones in the olive, the cerebellar cortex and the nuclei. The nucleo-olivary pathway is GABAergic, but several investigators argue that its main effect is to regulate electrotonic coupling between cells in the inferior olive rather than inhibit the olive. However, there is now strong evidence that the nucleo-olivary fibres do inhibit the olive. Three functions have been suggested for this inhibition: (i) feedback control of background activity in Purkinje cells, (ii) feedback control of learning, and (iii) gating of olivary input in general. Evidence is consistent with (i) and (ii). Activity in the nucleo-olivary pathway suppresses both synaptic transmission and background activity in the olive. When learned blink responses develop, the blink related part of the olive is inhibited while blinks are produced. When the nucleo-olivary pathway is interrupted, there is a corresponding increase in complex spike discharge in Purkinje cel...Continue Reading

References

Dec 15, 1976·The Journal of Comparative Neurology·D L TolbertP A Young
Mar 15, 1978·Experimental Brain Research·D L TolbertJ R Bloedel
Jan 1, 1991·Anatomy and Embryology·B J Fredette, E Mugnaini
Jan 1, 1988·Experimental Brain Research·G AnderssonG Hesslow
Jan 1, 1987·Experimental Brain Research·G Andersson, G Hesslow
May 1, 1974·Journal of Neurophysiology·R LlinasC Sotelo
Sep 12, 1983·Brain Research·N TsukaharaY Oda
Jan 1, 1981·Anatomy and Embryology·E Dietrichs, F Walberg
Apr 1, 1995·The European Journal of Neuroscience·T J Ruigrok, J Voogd
Sep 1, 1994·Neuroscience·S M Turgeon, R L Albin
Dec 1, 1993·Current Opinion in Neurobiology·R Llinás, J P Welsh
Jun 19, 1996·Annals of the New York Academy of Sciences·C I de Zeeuw, A S Berrebi
Jun 1, 1996·Experimental Brain Research·G Hesslow, M Ivarsson
Jan 1, 1997·Progress in Brain Research·T J Ruigrok
Sep 15, 1998·Trends in Neurosciences·C I De ZeeuwT J Ruigrok
Sep 14, 1999·Journal of Neurophysiology·D D MottD V Lewis
Oct 12, 1999·The Journal of Comparative Neurology·I SugiharaY Shinoda
Aug 16, 2000·Progress in Brain Research·R Apps

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Citations

Oct 22, 2008·The Cerebellum·Anders RasmussenGermund Hesslow
Oct 15, 2009·The Cerebellum·Marylka Uusisaari, Thomas Knöpfel
Feb 11, 2010·The Cerebellum·Mario Manto, Nordeyn Oulad Ben Taib
Dec 1, 2010·The Cerebellum·Marylka Uusisaari, Thomas Knöpfel
Sep 21, 2013·Proceedings of the National Academy of Sciences of the United States of America·Joseph ChaumontPhilippe Isope
Dec 1, 2006·The Cerebellum·Mario-Ubaldo Manto
Oct 5, 2011·Learning & Memory·John H Freeman, Adam B Steinmetz
May 1, 2008·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M Manto, M-A Laute
Jun 18, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tatyana YakushevaDora E Angelaki
Nov 25, 2014·The Cerebellum·Henrik Jörntell
Jul 20, 2014·Biological cybernetics·Fahad Sultan
Aug 23, 2007·Neuroreport·Fredrik BengtssonGermund Hesslow
Apr 28, 2011·The Journal of Physiology·Marylka Uusisaari, Erik De Schutter
Oct 28, 2015·Proceedings of the National Academy of Sciences of the United States of America·Anders RasmussenGermund Hesslow
Oct 26, 2010·Brain & Development·Mutsuki ShiodaMakiko Osawa
Aug 26, 2015·The Cerebellum·Egidio D'AngeloEduardo Ros
Jul 26, 2015·Neurobiology of Learning and Memory·Chen HuBo Hu
Oct 8, 2014·Brain Research·John H Freeman
Jan 23, 2013·Neural Networks : the Official Journal of the International Neural Network Society·Isao T TokudaMitsuo Kawato
Mar 29, 2013·Neural Networks : the Official Journal of the International Neural Network Society·Ivan Herreros, Paul F M J Verschure
May 24, 2008·Neuron·Ruben S Van Der GiessenChris I De Zeeuw
Apr 9, 2015·Frontiers in Computational Neuroscience·Sergio O Verduzco-Flores, Randall C O'Reilly
Aug 26, 2014·Frontiers in Bioengineering and Biotechnology·Ivan HerrerosPaul F M J Verschure
Aug 21, 2014·Frontiers in Neural Circuits·Anders RasmussenGermund Hesslow
May 21, 2016·Annals of the New York Academy of Sciences·Torgeir Moberget, Richard B Ivry
Dec 1, 2017·Brain Structure & Function·Joan S BaizerSandra F Witelson
Jan 27, 2018·Cerebellum & Ataxias·Elan D LouisPhyllis L Faust
Mar 13, 2019·PLoS Computational Biology·Niceto R LuqueAngelo Arleo
Jul 7, 2007·Journal of Neurophysiology·Fredrik Bengtsson, Henrik Jörntell
Dec 25, 2009·Journal of Neurophysiology·Pär SvenssonGermund Hesslow

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