Cerebellar degeneration associated with human immunodeficiency virus infection

Neurology
M TagliatiJ R Berger

Abstract

Cerebellar disorders associated with HIV infection are typically the result of discrete cerebellar lesions resulting from opportunistic infections such as toxoplasmosis and progressive multifocal leukoencephalopathy or primary CNS lymphoma. Clinical symptoms and pathologic abnormalities related to the cerebellum may also be observed with HIV dementia. A primary cerebellar degeneration with HIV has not previously been reported. Ten patients were identified over an 8-year period at five medical centers. All patients had clinical, laboratory, and radiologic evaluations, and three had neuropathologic examinations. Patients presented with progressively unsteady gait, slurred speech, and limb clumsiness. Examination revealed gait ataxia, impaired limb coordination, dysarthria, and abnormal eye movements. Cognition, strength, and sensory function remained normal. CD4 lymphocyte counts varied between 10 and 437 cells/mm3. Neuroimaging studies showed prominent cerebellar atrophy. Neuropathology showed focal degeneration of the cerebellar granular cell layer and unusual focal axonal swellings in the brainstem and spinal cord. Cultures, histopathology, and immunochemical studies showed no conclusive evidence of infection. We report a synd...Continue Reading

References

Feb 1, 1979·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·R Broughton, M Mamelak
Jan 1, 1988·Neurology·R J BartlettE Bakker
Jan 1, 1982·Annals of Neurology·R W Cutler, R B Spertell
Nov 1, 1994·Journal of Neurology, Neurosurgery, and Psychiatry·C VedelerJ A Aarli
Mar 1, 1994·Archives of Neurology·F CastellanosJ A Zabala
Jan 1, 1994·Neurology·M J KupersmithJ Whitaker
Jan 1, 1993·The Medical Clinics of North America·J R Berger, R M Levy
Feb 1, 1993·Neuropathology and Applied Neurobiology·F GrayB Hurtrel

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Citations

Sep 28, 2010·Brain Imaging and Behavior·Edith V SullivanAdolf Pfefferbaum
Dec 3, 1999·Journal of the Neurological Sciences·L AnderssonM Gisslén
Jun 1, 1999·Clinical Neurology and Neurosurgery·F SettaM U Manto
Feb 22, 2003·European Journal of Radiology·Edith V Sullivan, Adolf Pfefferbaum
Jan 23, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Maria CiardiSalvatore Delia
Sep 23, 2008·Neuroreport·Andrea D KlunderPaul M Thompson
Dec 17, 2009·Rinshō shinkeigaku = Clinical neurology·Seika NakamuraHirofumi Kusaka
Dec 24, 2008·Journal of Neuropathology and Experimental Neurology·Christian WüthrichIgor J Koralnik
Jan 20, 2010·Lancet Neurology·Thomas Klockgether
Sep 27, 2006·Clinics in Geriatric Medicine·Susan L Perlman
Jan 25, 2005·Psychiatry Research·Courtnay W BloomerDieter J Meyerhoff
Mar 25, 2016·Rinshō shinkeigaku = Clinical neurology·Shigeto NagaoSadayuki Matsumoto
Sep 15, 2015·Parkinsonism & Related Disorders·Han-Joon KimBeomseok Jeon
Jun 14, 2006·Seminars in Oncology·Robert B Darnell, Jerome B Posner
Sep 24, 2011·The Journal of General Virology·Xin DangIgor J Koralnik
May 25, 2015·Journal of the Neurological Sciences·Carole HenryThomas De Broucker
Apr 19, 2015·Current Opinion in Neurology·Dhanashri P Miskin, Igor J Koralnik
May 4, 2012·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Mônica Gomes da Silva
Jul 13, 2012·Journal of Clinical Neurology·Mi Jung KimSun Ju Chung
Dec 21, 2007·Arquivos de neuro-psiquiatria·Clécio de Oliveira Godeiro-JúniorAlberto Alain Gabbai
Jun 20, 2017·Case Reports in Neurology·Carolin HoyerMarc Fatar
Jun 9, 2018·BMJ Case Reports·Mohammad HeidaryKhashayar Afshari
Jan 29, 2020·Journal of Neurovirology·Carissa L PhilippiUNKNOWN SEARCH 010/RV254 and RV304/SEARCH 013 study teams
Jun 27, 2017·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Katherine M CliffordVictor G Valcour
May 16, 2017·Frontiers in Human Neuroscience·Sharif I KronemerCherie L Marvel
Sep 13, 2019·Neurology India·Vijay Sardana, Parag Moon
Apr 7, 2018·Frontiers in Aging Neuroscience·Natalie M Zahr

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