Cerebellar direct current stimulation modulates pain perception in humans

Restorative Neurology and Neuroscience
Tommaso BocciFerdinando Sartucci

Abstract

The cerebellum is involved in a wide number of integrative functions, but its role in pain experience and in the nociceptive information processing is poorly understood. In healthy volunteers we evaluated the effects of transcranial cerebellar direct current stimulation (tcDCS) by studying the changes in the perceptive threshold, pain intensity at given stimulation intensities (VAS:0-10) and laser evoked potentials (LEPs) variables (N1 and N2/P2 amplitudes and latencies). Fifteen subjects were studied before and after anodal, cathodal and sham tcDCS. LEPs were obtained using a neodymium:yttrium-aluminium-perovskite (Nd:YAP) laser and recorded from the dorsum of the left hand. VAS was evaluated by delivering laser pulses at two different intensities, respectively two and three times the perceptive threshold. Cathodal polarization dampened significantly the perceptive threshold and increased the VAS score, while the anodal one had opposite effects. Cathodal tcDCS increased significantly the N1 and N2/P2 amplitudes and decreased their latencies, whereas anodal tcDCS elicited opposite effects. Motor thresholds assessed through transcranial magnetic stimulation were not affected by cerebellar stimulation. tcDCS modulates pain percep...Continue Reading

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Citations

Feb 6, 2016·The Cerebellum·Tommaso BocciEnrica L Santarcangelo
Dec 15, 2015·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·A J WoodsM A Nitsche
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Jan 10, 2018·Neuromodulation : Journal of the International Neuromodulation Society·Tommaso BocciFerdinando Sartucci
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Jan 9, 2020·The International Journal of Clinical and Experimental Hypnosis·Edoardo CasigliaAnnalena Venneri
Jun 6, 2019·The Cerebellum·Lauren N MiterkoRoy V Sillitoe
Aug 28, 2020·Expert Review of Medical Devices·Kevin Pacheco-BarriosFelipe Fregni
Dec 11, 2020·Brain Sciences·Rubens Gisbert CuryDaniel Ciampi de Andrade
Dec 18, 2020·Frontiers in Human Neuroscience·Laura Torrecillas-MartínezPablo Galindo-Moreno

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