Cerebellar Expression of the Neurotrophin Receptor p75 in Naked-Ataxia Mutant Mouse

International Journal of Molecular Sciences
Maryam Rahimi BalaeiHassan Marzban

Abstract

Spontaneous mutation in the lysosomal acid phosphatase 2 (Acp2) mouse (nax--naked-ataxia mutant mouse) correlates with severe cerebellar defects including ataxia, reduced size and abnormal lobulation as well as Purkinje cell (Pc) degeneration. Loss of Pcs in the nax cerebellum is compartmentalized and harmonized to the classic pattern of gene expression of the cerebellum in the wild type mouse. Usually, degeneration starts in the anterior and posterior zones and continues to the central and nodular zones of cerebellum. Studies have suggested that the p75 neurotrophin receptor (NTR) plays a role in Pc degeneration; thus, in this study, we investigated the p75NTR pattern and protein expression in the cerebellum of the nax mutant mouse. Despite massive Pc degeneration that was observed in the nax mouse cerebellum, p75NTR pattern expression was similar to the HSP25 pattern in nax mice and comparable with wild type sibling cerebellum. In addition, immunoblot analysis of p75NTR protein expression did not show any significant difference between nax and wild type sibling (p > 0.5). In comparison with wild type counterparts, p75NTR pattern expression is aligned with the fundamental cytoarchitecture organization of the cerebellum and is ...Continue Reading

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Citations

Jun 18, 2018·The Cerebellum·Maryam Rahimi-BalaeiHassan Marzban
Jan 9, 2019·Frontiers in Cellular Neuroscience·Maryam Rahimi-BalaeiHassan Marzban

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Methods Mentioned

BETA
transgenic
PCR
fluorescence microscopy

Software Mentioned

AxioVision
Zeiss Z2 Imager
Adobe Photoshop
Zen
SPSS

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