Cerebellar granule cell: ascending axon and parallel fiber

The European Journal of Neuroscience
Chiming HuangRosa H Huang

Abstract

Morphometric data have indicated that most (> 95%) of the granule cell axonal synapses are located along the parallel fibers. The ascending axons of granule cells, however, exert powerful excitatory effects on the activities of Purkinje cells. To resolve this apparent conflict, we propose that some of the parallel fiber synapses overlying a functionally homogeneous granule cell patch can discharge in close synchrony with the ascending axon synapses from that same granule cell patch, thereby augmenting the excitatory action from ascending axons. Moreover, we also propose that age may be an important factor in the ascending axon synapses. We examined the synaptic varicosities along the ascending axons and parallel fibers in the anterior lobe of the male NIA C57BL/6j mouse. Between 2.5 and 10 months, the fraction of synaptic varicosities anatomically associated with the ascending axons increased from 2.6% to 6.6% whereas the fraction of synaptic varicosities that can discharge in synchrony with ascending axon synapses (including some parallel fiber synapses) increased from 17.3% to 39% (assuming a granule cell patch of 300 x 300 microm). The results of the present study may be relevant to understanding the role of the ascending ax...Continue Reading

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Citations

Jul 24, 2010·Cell and Tissue Research·Changzheng ZhangTianmiao Hua
Apr 18, 2008·The Cerebellum·Chiming Huang
Nov 14, 2008·Journal of Neurophysiology·Michael E Brown, Michael Ariel
Jul 12, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Samuel W CramerTimothy J Ebner
Jul 28, 2016·Frontiers in Cellular Neuroscience·Egidio D'AngeloEduardo Ros
Feb 17, 2017·Scientific Reports·Chandramohan SubashiniJackson James
Jun 4, 2019·Frontiers in Neuroinformatics·Stefano CasaliEgidio D'Angelo

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