Cerebellar Hippocampal and Basal Nuclei Transient Edema with Restricted diffusion (CHANTER) Syndrome.

Neurocritical Care
Adam S JasneDaniel Kanter

Abstract

Abnormal restricted diffusion on magnetic resonance imaging is often associated with ischemic stroke or anoxic injury, but other conditions can present similarly. We present six cases of an unusual but consistent pattern of restricted diffusion in bilateral hippocampi and cerebellar cortices. This pattern of injury is distinct from typical imaging findings in ischemic, anoxic, or toxic injury, suggesting it may represent an under-recognized clinicoradiographic syndrome. Despite initial presentation with stupor or coma in the context of obstructive hydrocephalus, patients may have acceptable outcomes if offered early intervention. We identified an ad hoc series of patients at our two institutions between years 2014 and 2017 who presented to the neurocritical care unit with severe, otherwise unexplained cerebellar edema and retrospectively identified several commonalities in history, presentation, and imaging. Between two institutions, we identified six patients-ages 33-59 years, four male-with similar presentations of decreased level of consciousness in the context of intoxicant exposure, with acute cytotoxic edema of the cerebellar cortex, hippocampi, and aspects of the basal nuclei. All patients presented with severe cerebella...Continue Reading

References

Jan 11, 1976·Archives of Neurology·M D GinsbergE P Richardson
Jan 1, 1989·Journal of Neuropathology and Experimental Neurology·T SarafianM A Verity
Dec 4, 1982·Lancet·E C WoltersB Verbeeten
Apr 30, 1998·Journal of Magnetic Resonance Imaging : JMRI·Y KorogiK Eto
Jan 11, 2001·Neuroradiology·R NananM Warmuth-Metz
Feb 20, 2003·AJR. American Journal of Roentgenology·Ciaran F KeoghDouglas A Graeb
Sep 15, 2006·Journal of Child Neurology·Marisol AnselmoDeolinda Barata
Jun 21, 2007·Anesthesia and Analgesia·W Andrew KofkeJohn Detre
Aug 19, 2007·AJNR. American Journal of Neuroradiology·W S Bartynski, J F Boardman
Sep 22, 2007·AJR. American Journal of Roentgenology·Chung-Ping LoGuo-Shu Huang
Nov 4, 2008·Clinical Neurology and Neurosurgery·Praveen K GuptaP J Sudhakar
Sep 16, 2009·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Justyna R SarnaSarah Furtado
Oct 8, 2009·Journal of Child Neurology·Anna ZaninAnna Maria Laverda
May 5, 2010·Neurocritical Care·Yazmin Morales OdiaWendy C Ziai
Jun 30, 2010·Neuroradiology·Leonardo Guilhermino GutierrezLeandro Tavares Lucato
Jul 3, 2010·Stroke; a Journal of Cerebral Circulation·Michael MlynashChristine A C Wijman
Jan 18, 2011·Practical Neurology·Robin S HowardMichalis A Koutroumanidis
Jun 30, 2012·International Journal of Emergency Medicine·Ryan A StephenCostello J Daniel
Dec 21, 2012·The British Journal of Radiology·M L WhiteM F Omojola
Oct 16, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Andrew J GrossbachJeremy D W Greenlee
Apr 24, 2015·Neurology·Diep Ho BuiCiro Ramos-Estebanez
Sep 5, 2015·Journal of Neurosurgery. Pediatrics·Andrew ReisnerJoshua J Chern
Jul 29, 2016·Neurocase·Juan E SmallJed A Barash
Jan 6, 2017·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Shamik BhattacharyyaJoshua P Klein
Jan 27, 2017·MMWR. Morbidity and Mortality Weekly Report·Jed A BarashAlfred DeMaria
Mar 22, 2018·The New England Journal of Medicine·Jed A BarashAlfred DeMaria
Sep 19, 2018·Radiology·Jed A Barash, Michael H Lev

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.