Cerebellar influence on olivary excitability in the cat

The European Journal of Neuroscience
T J H Ruigrok, J Voogd

Abstract

This study examines the influence of the cerebellum on the excitability of inferior olivary neurons in the cat. Two major pathways from the cerebellar nuclei to the inferior olive have been investigated by electrophysiological and anatomical techniques. The first, excitatory pathway connects the cerebellar nuclei through nuclei at the mesodiencephalic junction with the inferior olive. The second is the direct, GABAergic, nucleo-olivary pathway. Intra- as well as extracellular recordings obtained in the rostral part of the medial accessory and principal olives revealed that electrical stimulation with a short burst of three pulses delivered at the mesodiencephalic junction results in short-latency activation (4-8 ms) of most olivary neurons. More than half of the units showed, in addition to the short-latency activation, a consistent response with a much longer latency (approximately 180 ms). Many units (66%) that responded to mesodiencephalic stimulation could also be activated by superior cerebellar peduncle stimulation with a similar stimulation paradigm (latency 9-15 ms). However, in such cases consistent long-latency responses were only rarely recorded (7%). To distinguish between the effect of the two pathways, both of whi...Continue Reading

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Citations

Sep 12, 2000·The Journal of Comparative Neurology·T J Ruigrok, J Voogd
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