Cerebellar input to corticothalamic neurons in layers V and VI in the motor cortex

Neuroscience Research
J NaY Shinoda

Abstract

To investigate whether corticothalamic (CT) neurons in the motor cortex (Mx) receive cerebellar input via the ventroanterior-ventrolateral nucleus of the thalamus (VA-VL), we recorded intracellular potentials from neurons in the Mx of anesthetized cats and examined effects of stimulation of the VA-VL and the brachium conjunctivum on them. After this electrophysiological identification, horseradish peroxide (HRP) was injected iontophoretically into the recorded neurons for morphological analysis. We identified 34 neurons as CT neurons by their antidromic response to stimulation of the VA-VL, of which 13 were layer VI CT neurons and 21 were layer V CT neurons. A majority of the CT neurons of both layers VI and V received monosynaptic excitatory postsynaptic potentials (EPSPs) from the VA-VL and di- or polysynaptic EPSPs from the cerebellum. The laminar distribution and morphological characteristics of single CT neurons receiving cerebellar input were analyzed on 19 HRP-labeled CT neurons. Eight layer V and six layer VI CT neurons were reconstructed from serial sections. All the reconstructed layer VI CT neurons were modified pyramidal neurons whose apical dendrites ended in layer III or V, and all the stained layer V CT neurons w...Continue Reading

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Citations

Nov 24, 2004·Experimental Brain Research·Nobue Kobayashi IwataYoshikazu Ugawa
Aug 19, 2006·Experimental Brain Research·Brigida FierroFilippo Brighina
Jan 7, 2004·Journal of the Neurological Sciences·Stefano TamburinGiampietro Zanette
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Jul 30, 2014·Nature Neuroscience·Rémi D ProvilleClément Léna
Jul 17, 2010·Brain Stimulation·T PopaS Meunier
Mar 30, 2004·The Journal of Physiology·Zafiris J DaskalakisRobert Chen
Nov 17, 2009·The European Journal of Neuroscience·Laura AvanzinoGiovanni Abbruzzese
Sep 11, 2014·Experimental Neurology·Diellor BashaWilliam D Hutchison
Jan 7, 2020·Neurorehabilitation and Neural Repair·Keerthana Deepti KarunakaranBharat B Biswal
Nov 22, 2018·Frontiers in Cellular Neuroscience·Elena Laura GeorgescuDaniela Popa
Jul 19, 2000·Journal of Neurophysiology·R N HoldeferJ C Houk
Dec 7, 2019·The Journal of Comparative Neurology·Ashley J SwainYoland Smith
Feb 6, 2021·Scientific Reports·Martje G PaulyAnne Weissbach
Aug 9, 2008·Brain Research Reviews·Sylco S HoppenbrouwersZafiris J Daskalakis

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