Cerebellar Intermittent Theta-Burst Stimulation Combined with Vestibular Rehabilitation Improves Gait and Balance in Patients with Multiple Sclerosis: a Preliminary Double-Blind Randomized Controlled Trial.

The Cerebellum
Marco TramontanoGiacomo Koch

Abstract

Difficulties in gait and balance disorders are among the most common mobility limitations in multiple sclerosis (MS), mainly due to a damage of cerebellar circuits. Moreover, the cerebellum plays a critical role in promoting new motor tasks, which is an essential function for neurorehabilitation. In this study, we investigated the effects of cerebellar intermittent theta burst stimulation (c-iTBS), a high-frequency rTMS protocol able to increase cerebellar activity, on gait and balance in a sample of 20 hospitalized participants with MS, undergoing vestibular rehabilitation (VR), an exercise-based program primarily designed to reduce vertigo and dizziness, gaze instability, and/or imbalance and falls in MS. Patients were assigned to receive either c-iTBS or sham iTBS before being treated with VR during 2 weeks. VR consisted of two types of training: gaze stability and postural stability exercises. The primary outcome measure was the change from baseline in the Tinetti Balance and Gait scale (TBG). The secondary outcome measures were changes from baseline in Berg Balance Scale (BBS), Fatigue Severity Scale (FSS), Two Minute Walking Test (2MWT), and Timed 25-ft walk test (T25FW) scales. MS patients treated with c-iTBS-VR showed a...Continue Reading

References

Jun 4, 1999·Brain : a Journal of Neurology·G R CutterE Willoughby
Jun 25, 2008·Multiple Sclerosis : Clinical and Laboratory Research·G KochD Centonze
Jun 12, 2014·Progress in Brain Research·Egidio D'Angelo
Dec 26, 2017·Gait & Posture·Valeria BelluscioGiuseppe Vannozzi
May 11, 2018·European Journal of Physical and Rehabilitation Medicine·Sonia BonnìAntonella Peppe

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Citations

Feb 6, 2021·The Cerebellum·Andrea PilottoAlessandro Padovani
Mar 25, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Luana Billeri, Antonino Naro

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