Cerebellar involvement in motor but not sensory adaptation.

Neuropsychologia
Hannah J Block, Amy J Bastian

Abstract

Predictable sensorimotor perturbations can lead to cerebellum-dependent adaptation--i.e., recalibration of the relationship between sensory input and motor output. Here we asked if the cerebellum is also needed to recalibrate the relationship between two sensory modalities, vision and proprioception. We studied how people with and without cerebellar damage use visual and proprioceptive signals to estimate their hand's position when the sensory estimates disagree. Theoretically, the brain may resolve the discrepancy by recalibrating the relationship between estimates (sensory realignment). Alternatively, the misalignment may be dealt with by relying less on one sensory estimate and more on the other (a weighting strategy). To address this question, we studied subjects with cerebellar damage and healthy controls as they performed a series of tasks. The first was a prism adaptation task that involves motor adaptation to compensate for a visual perturbation and is known to require the cerebellum. As expected, people with cerebellar damage were impaired relative to controls. The same subjects then performed two experiments in which they reached to visual and proprioceptive targets while a visuoproprioceptive misalignment was gradual...Continue Reading

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Citations

May 28, 2013·Experimental Brain Research·Danielle SalomonczykDenise Y P Henriques
May 24, 2013·Experimental Brain Research·Timothy P LillicrapJuan Fernandez-Ruiz
Mar 24, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jun IzawaReza Shadmehr
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Aug 25, 2020·Clinical Biomechanics·Amanda E Stone, Chris J Hass

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