PMID: 2092587Jan 1, 1990Paper

Cerebellar micropolygyria in Fukuyama congenital muscular dystrophy: observations in fetal and pediatric cases

Brain & Development
K Takada, H Nakamura

Abstract

Cerebeller micropolygyria in Fukuyama congenital muscular dystrophy (FCMD) was examined neuropathologically by three-dimensional reconstruction and immunohistochemistry in one fetal and two children's cases. In the children's cases, a complex columnar network of the molecular layer was mixed with clusters of the granular cell layers, often associated with central blood vessels. Although primitive, cortical dysplasia was also obvious in the fetal cerebellum at 23 weeks of gestation. Ectopic glial proliferation was less extensive than that in the cerebral cortex. It is suggested that leptomeningeal disruption, superficial proliferation of mesenchymal tissue and subsequent mixture of neuroglial and mesenchymal tissues, which may occur transiently during the fetal period in the developing FCMD cerebellum as well as in the cerebrum, play substantial roles in the development of cerebellar cortical dysplasia.

References

Aug 7, 1978·Acta Neuropathologica·R L Friede, J Mikolasek
Jul 1, 1976·Archives of Neurology·S KamoshitaY Fukuyama
Jan 1, 1986·Anatomy and Embryology·J SieversM Berry
Jan 1, 1972·Acta Neuropathologica·G A de León
Jul 1, 1984·Journal of Neuropathology and Experimental Neurology·K TakadaJ Tanaka

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Citations

Apr 30, 1998·Journal of Magnetic Resonance Imaging : JMRI·N Aida
Aug 1, 1994·Neuroradiology·L ValanneP Santavuori
Sep 1, 1991·Journal of the Neurological Sciences·E ArikawaK Arahata
Jun 18, 1998·Arquivos de neuro-psiquiatria·L C WerneckF M Iwamoto
Nov 1, 1996·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·A J Barkovich, R I Kuzniecky
Jul 1, 1994·Child: Care, Health and Development·N Gordon
Dec 12, 2007·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Norbert UlfigPayam Rezaie
Mar 15, 2001·Brain & Development·C P TrevisanS Lombardi
Oct 11, 2007·Annals of Neurology·A James BarkovichWilliam B Dobyns
Sep 8, 2004·Brain Research. Developmental Brain Research·Eiko Ohtsuka-TsurumiMakiko Osawa
Jul 10, 2004·Journal de radiologie·G Soto AresJ-P Pruvo

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