Cerebellar motor function in spina bifida meningomyelocele.

The Cerebellum
Maureen DennisJack M Fletcher

Abstract

Spina bifida meningomyelocele (SBM), a congenital neurodevelopmental disorder, involves dysmorphology of the cerebellum, and its most obvious manifestations are motor deficits. This paper reviews cerebellar neuropathology and motor function across several motor systems well studied in SBM in relation to current models of cerebellar motor and timing function. Children and adults with SBM have widespread motor deficits in trunk, upper limbs, eyes, and speech articulators that are broadly congruent with those observed in adults with cerebellar lesions. The structure and function of the cerebellum are correlated with a range of motor functions. While motor learning is generally preserved in SBM, those motor functions requiring predictive signals and precise calibration of the temporal features of movement are impaired, resulting in deficits in smooth movement coordination as well as in the classical cerebellar triad of dysmetria, ataxia, and dysarthria. That motor function in individuals with SBM is disordered in a manner phenotypically similar to that in adult cerebellar lesions, and appears to involve similar deficits in predictive cerebellar motor control, suggests that age-based cerebellar motor plasticity is limited in individ...Continue Reading

References

Feb 1, 1977·American Journal of Diseases of Children·P L Soare, A J Raimondi
Sep 1, 1979·Journal of Speech and Hearing Research·R D KentJ H Abbs
Apr 1, 1992·Developmental Medicine and Child Neurology·G McEneryB G Neville
Dec 1, 1990·Neurology·A C ArnoldR S Hepler
Mar 1, 1990·Archives of Neurology·S S MossmanP Rudge
May 1, 1990·Developmental Medicine and Child Neurology·G Lennerstrand, J E Gallo
May 1, 1990·Developmental Medicine and Child Neurology·G LennerstrandL Samuelsson
Jan 1, 1989·Pediatric Neuroscience·D G McLone, P A Knepper
Dec 1, 1988·Zeitschrift Für Kinderchirurgie : Organ Der Deutschen, Der Schweizerischen Und Der Osterreichischen Gesellschaft Für Kinderchirurgie = Surgery in Infancy and Childhood·A M PearsonM D Hallwell
Oct 1, 1987·Journal of Clinical and Experimental Neuropsychology·M DennisR P Humphreys
Dec 1, 1986·Developmental Medicine and Child Neurology·A Turner
Mar 1, 1985·The Journal of Bone and Joint Surgery. British Volume·A Turner
Jan 1, 1985·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·H K ZeinerR V Smith
Jan 1, 1973·Developmental Medicine and Child Neurology. Supplement·S J Wallace
Jun 1, 1969·The Journal of Physiology·D Marr
Jun 1, 1969·Journal of Speech and Hearing Research·F L DarleyJ R Brown
Jan 1, 1967·Progress in Brain Research·V Braitenberg
Oct 1, 1981·Archives of Neurology·M DennisR P Humphreys
May 1, 1980·The Australian & New Zealand Journal of Obstetrics & Gynaecology·G Jenkin
Mar 1, 1981·Brain : a Journal of Neurology·J W Spooner, R W Baloh
May 1, 1996·Journal of Neurology, Neurosurgery, and Psychiatry·G DeuschlM Hallett
Dec 1, 1996·Current Opinion in Neurobiology·R B Ivry
Mar 13, 1998·European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie·W J Muen, C M Bannister
Oct 17, 1998·Journal of Neurophysiology·M TakagiR J Tamargo
Apr 10, 1999·Nature Neuroscience·S J BlakemoreC D Frith
Aug 24, 1999·Developmental Medicine and Child Neurology·E N WilliamsM B Menelaus
Nov 26, 1999·JAMA : the Journal of the American Medical Association·J P BrunerG W Reed
Dec 22, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·D W Crimmins, J D Palmer
Dec 22, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·J M Pearce
Feb 11, 2000·Psychological Bulletin·C L Krumhansl
Jun 15, 2000·Experimental Brain Research·M DesmurgetS T Grafton
Jul 19, 2000·Current Biology : CB·M D MaukT Ohyama
Aug 1, 2000·Developmental Neuropsychology·S H MostofskyM B Denckla
Aug 16, 2000·Neuroreport·S J BlakemoreC Frith
Sep 30, 2000·Journal of the International Neuropsychological Society : JINS·R HetheringtonB Spiegler
May 23, 2001·Nature Neuroscience·M Iacoboni
Jul 19, 2001·Annals of the New York Academy of Sciences·T D Griffiths

❮ Previous
Next ❯

Citations

Jan 10, 2013·Journal of the International Neuropsychological Society : JINS·Heather B TaylorFurong Huang
Oct 1, 2011·Journal of Integrative Neuroscience·Egidio D'Angelo
Feb 18, 2014·Journal of the International Neuropsychological Society : JINS·Amery Treble-BarnaJack M Fletcher
Jun 30, 2014·Journal of the Neurological Sciences·Dongwhane LeeTae-Beom Ahn
May 14, 2014·Neuropsychology Review·Maureen DennisJack M Fletcher
Nov 28, 2013·Developmental Medicine and Child Neurology·Koenraad N J A Van Braeckel, H Gerry Taylor
Apr 27, 2010·Developmental Disabilities Research Reviews·Jenifer Juranek, Michael S Salman
Jan 1, 2015·Nature Reviews. Disease Primers·Andrew J CoppGary M Shaw
Oct 17, 2012·Developmental Neuropsychology·Anja VinckMaria W G Nijhuis-van der Sanden
Mar 14, 2019·Journal of the International Neuropsychological Society : JINS·Paul T CirinoMaureen Dennis
Apr 2, 2019·American Journal of Physical Medicine & Rehabilitation·Anne C TitaBrad E Dicianno
Oct 2, 2019·Neurosurgical Focus·Sophie FossJane E Schreiber
Aug 14, 2020·Anatomical Science International·Funmilayo Eniola OlopadeMatthew Temitayo Shokunbi
Oct 22, 2019·Journal of Motor Behavior·Kardelen Gencer-AtalayAdnan Dagcinar
Nov 16, 2019·Journal of the International Neuropsychological Society : JINS·Ashley L WareJack M Fletcher
May 10, 2019·The Journal of Surgical Research·Marc OriaJose L Peiro
Aug 31, 2021·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Leonie SchafmeyerIbrahim Duran
Oct 7, 2021·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Fabienne PaschereitAngela M Kaindl

❮ Previous
Next ❯

Related Concepts

Related Feeds

Ataxias (MDS)

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

Ataxia

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

Ataxias

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on different types of ataxias here.

Ataxia telangiectasia (MDS)

Ataxia telangiectasia is a rare neurodegenerative diseases caused by defects in the ATM gene, which is involved in DNA damage recognition and repair pathways. Here is the latest research on this autosomal recessive disease.

Related Papers

Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery
Derryn JewellMaureen Dennis
Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery
Maureen DennisFred Gentili
Journal of the International Neuropsychological Society : JINS
Maureen DennisJack M Fletcher
© 2021 Meta ULC. All rights reserved