Cerebellar plasticity and associative memories are controlled by perineuronal nets

Proceedings of the National Academy of Sciences of the United States of America
Daniela CarulliJoost Verhaagen

Abstract

Perineuronal nets (PNNs) are assemblies of extracellular matrix molecules, which surround the cell body and dendrites of many types of neuron and regulate neural plasticity. PNNs are prominently expressed around neurons of the deep cerebellar nuclei (DCN), but their role in adult cerebellar plasticity and behavior is far from clear. Here we show that PNNs in the mouse DCN are diminished during eyeblink conditioning (EBC), a form of associative motor learning that depends on DCN plasticity. When memories are fully acquired, PNNs are restored. Enzymatic digestion of PNNs in the DCN improves EBC learning, but intact PNNs are necessary for memory retention. At the structural level, PNN removal induces significant synaptic rearrangements in vivo, resulting in increased inhibition of DCN baseline activity in awake behaving mice. Together, these results demonstrate that PNNs are critical players in the regulation of cerebellar circuitry and function.

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Citations

Oct 18, 2020·The Journal of Comparative Neurology·Jacob A EdwardsKim L Hoke
Oct 29, 2020·Journal of Neurophysiology·Reza Shadmehr
Dec 8, 2020·Neurobiology of Learning and Memory·Deidre E O'DellDesheng Wang
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Dec 17, 2020·Journal of Neurophysiology·Nina L de OudeHenk-Jan Boele
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Jan 9, 2021·Neural Development·Nelson A Perez-CatalanSarah D Ackerman
Nov 17, 2020·Frontiers in Systems Neuroscience·Marta MiquelJulian Guarque-Chabrera
Mar 7, 2021·International Journal of Molecular Sciences·Daniela Carulli, Joost Verhaagen
Jun 16, 2021·Cellular and Molecular Life Sciences : CMLS·Egor DzyubenkoDirk M Hermann
Jul 2, 2021·Frontiers in Neural Circuits·Moritoshi HironoYuchio Yanagawa
Jun 19, 2021·Neurobiology of Stress·Pascal IbrahimGustavo Turecki
Jul 18, 2021·Molecular Psychiatry·Sujeong YangJames W Fawcett
Aug 21, 2021·Cellular & Molecular Immunology·Joshua D CrapserKim N Green
Aug 21, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Julian Guarque-ChabreraMarta Miquel

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BETA
electron microscopy

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