Cerebellar Processing Common to Delay and Trace Eyelid Conditioning

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Hunter E HalversonM Mauk

Abstract

Results from previous lesion studies have been interpreted as evidence that the cerebellar cortex plays different roles for delay and trace conditioning of eyelid responses. However, the cerebellar cortex is organized by parasagittal stripes of Purkinje cells (PCs) that converge onto common deep nucleus neurons and receive common or related climbing fiber inputs. Based on this organization, we hypothesized that cerebellar tasks involving the same response system, such as delay and trace eyelid conditioning, would engage the same PCs and that the relationships between PC activity and expression of behavioral responses would be similar for both tasks. To test these hypotheses, we used tetrode recordings from eyelid PCs in rabbits during expression of delay- and trace-conditioned eyelid responses. Previous recording studies during delay conditioning described a strong relationship between eyelid PC activity and the kinematics of conditioned eyelid responses. The present results replicate these findings for delay conditioning and show that the same relationship exists during trace eyelid conditioning. During transitions from delay to trace responding, the relationship between eyelid PCs and behavioral responses was relatively stabl...Continue Reading

Citations

Aug 10, 2020·Nature Communications·Seth W EggerMehrdad Jazayeri
Sep 19, 2020·Neural Computation·Terence D Sanger, Mitsuo Kawato

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