Cerebellar role in Parkinson's disease

Journal of Neurophysiology
Jasmine L Mirdamadi

Abstract

Parkinson's disease (PD) is a common neurodegenerative disorder associated with motor and cognitive impairments. The mechanisms underlying the pathophysiology and treatments have traditionally focused on basal ganglia-thalamo-cortical pathways due to striatal dopamine loss, but more recent evidence has highlighted the role of the cerebellum. In this Neuro Forum article, I review evidence from neuroimaging and noninvasive brain stimulation that demonstrates altered cerebellar activity in PD may be both a pathophysiological and compensatory mechanism depending on dopaminergic medication and symptoms.

References

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Citations

Jan 27, 2017·Journal of Movement Disorders·Kaoru Takakusaki
Jun 9, 2019·Journal of Neuroengineering and Rehabilitation·Rocco Salvatore CalabròPlacido Bramanti
Aug 15, 2020·Annals of Clinical and Translational Neurology·Yanyan KongYihui Guan
Sep 15, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Jin Ho JungPhil Hyu Lee
May 2, 2018·Journal of Parkinson's Disease·Craig F FerrisMalav Trivedi
Apr 13, 2018·Nature Reviews. Neuroscience·Andreea C Bostan, Peter L Strick
Mar 2, 2021·Parkinsonism & Related Disorders·Jihyun YangNadeeka N Dissanayaka
Jul 24, 2018·Journal of the Neurological Sciences·Xinxin MaHaibo Chen

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