PMID: 109292Jun 1, 1979

Cerebellar stimulation in alumina-gel monkey model: inverse relationship between clinical seizures and EEG interictal bursts

J S LockardL L DuCharme


The efficacy of cerebellar stimulation was addressed in a chronic monkey model (N = 12) of spontaneous focal motor and secondarily generalized seizures using 24 hr seizure frequency monitoring and all-night EEG recording. The anterior cerebellar vermis was stimulated employing parameters similar to those used in man, 10 Hz, 1 msec pulses, 10 min on, 10 off, at an average current of 2.0 mA. Six weeks pre- and post-base-line periods were compared to a stimulation period of the same length. The results contribute to a clarification of conflicting findings of previous researchers by revealing an inverse relationship between seizure frequency and interictal EEG bursts during the weeks of stimulation. Seizure frequency increased significantly and interictal bursts decreased. Both of these effects (especially the former) were evident in the post-stimulation period, but for different reasons than hypothesized for the period of stimulation. Whereas the therapeutic value of cerebellar stimulation on seizures may be in question, its utilization in the study of mechanisms of epilepsy may be warranted.


May 1, 1978·Journal of Neurosurgery·R D PennG C Agarwal
Sep 1, 1977·Journal of Neurosurgery·W J BrownP H Crandall
Dec 1, 1977·Epilepsia·J S LockardK E Hurlburt
Jan 1, 1978·Journal of Neurosurgery·H BantliE Sandberg
Aug 1, 1976·Archives of Neurology·I S CooperT P Poon


Jul 16, 1979·Life Sciences·A B Harris, J S Lockard
Oct 1, 2009·Neuromodulation : Journal of the International Neuromodulation Society·Sean Jeremy Nagel, Imad Michel Najm
May 22, 1998·Epilepsia·G A Ojemann
Aug 3, 2010·Neurosurgical Focus·Kostas N FountasGeorgios Hadjigeorgiou
Oct 1, 1980·Journal of Neurosurgery·L T Robertson, W L Smith
Apr 1, 1987·Journal of Neurosurgery·G A Ojemann
Apr 9, 2014·Nature Reviews. Neurology·R S Fisher, Ana Luisa Velasco
Jul 30, 1984·Brain Research·J MajkowskiR Haddad
Dec 22, 2017·Brain Sciences·Timothy Marc Eastin, Miguel Angel Lopez-Gonzalez
Feb 1, 1981·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·J Gaito, S T Gaito

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