Cerebellar stroke impairs temporal but not spatial accuracy during implicit motor learning

Neurorehabilitation and Neural Repair
L A Boyd, C J Winstein

Abstract

Numerous studies have demonstrated cerebellar activity during implicit motor learning, but few have addressed its specific role. The purpose of this study was to determine if specific components (spatial or temporal) of an implicit motor-tracking task were affected by cerebellar stroke. The authors studied the performance of individuals with unilateral cerebellar stroke (n = 7)and a control group (n = 10) across 3 acquisition days and at a delayed retention test as they practiced a unimanual tracking task with the contralesional upper extremity. After cerebellar stroke, participants demonstrated reduced tracking errors for repeating sequences compared to random sequences; however, decomposition of tracking performance into temporal and spatial components revealed persistent deficits in tracking time lag despite improved spatial accuracy. A lesion analysis showed that the dentate nucleus was the only common region affected by all cerebellar strokes. During implicit motor learning, the cerebellum appears to participate in the formation of predictive strategies for the timing of motor responses, rather than for the accuracy of motor execution. Because deficits were found in the contralesional upper extremity, the authors suggest t...Continue Reading

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Citations

Aug 3, 2011·Proceedings of the National Academy of Sciences of the United States of America·Xiang WuKhalaf O Bushara
Jun 27, 2006·Journal of Neurologic Physical Therapy : JNPT·Lara Boyd, Carolee Winstein
Nov 21, 2007·Journal of Neurologic Physical Therapy : JNPT·Eric D Vidoni, Lara A Boyd
Sep 30, 2008·Physiotherapy Theory and Practice·Nicola Saywell, Denise Taylor
Feb 11, 2011·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Sean K MeehanLara A Boyd
Sep 23, 2011·Human Brain Mapping·Michael KüperDagmar Timmann
Jul 28, 2013·Physiotherapy Theory and Practice·Cecelia Sartor-Glittenberg, Lori Brickner
Dec 15, 2010·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Jill G ZwickerLara A Boyd
Jul 29, 2015·Current Physical Medicine and Rehabilitation Reports·Elizabeth R Skidmore
Jul 15, 2016·Medicine and Science in Sports and Exercise·Cameron S MangLara A Boyd
Dec 9, 2016·Disability and Rehabilitation·Melanie K FlemingJohn C Rothwell
Oct 23, 2010·Neurorehabilitation and Neural Repair·Francesca GelfoFrancesco Angelucci
Dec 6, 2011·Neurorehabilitation and Neural Repair·Ichiro MiyaiUNKNOWN Cerebellar Ataxia Rehabilitation Trialists Collaboration
Dec 31, 2008·Clinical Rehabilitation·C L MartinA Bialocerkowski
Jan 2, 2007·Physical Therapy·Lara A Boyd
Jan 28, 2009·Neurorehabilitation and Neural Repair·Catherine Siengsukon, Lara A Boyd
Apr 10, 2007·Neurorehabilitation and Neural Repair·Lara A BoydCarolee J Winstein
Jul 9, 2005·Current Opinion in Neurology·Christian Forkstam, Karl Magnus Petersson
Dec 1, 2011·Paladyn : Journal of Behavioral Robotics·Ismet HandzicKyle B Reed
Aug 13, 2013·Journal of Neurologic Physical Therapy : JNPT·Michael R BorichLara A Boyd
Feb 10, 2009·Physical Therapy·Catherine F Siengsukon, Lara A Boyd
Dec 1, 2017·Journal of Motor Behavior·Yoshihiro Itaguchi, Kazuyoshi Fukuzawa
Sep 25, 2017·Scientific Reports·Cameron S MangLara A Boyd
Jan 23, 2016·Experimental Brain Research·Rami J HamzeyErin V L Vasudevan
Oct 28, 2017·Experimental Brain Research·Jessica Baird, Jill Campbell Stewart
Sep 15, 2017·Journal of Neurophysiology·Sandeep K SubramanianMindy F Levin
Jul 29, 2011·Journal of Neurophysiology·Angela L HewittTimothy J Ebner
Nov 21, 2020·Brain Communications·Svenja EspenhahnNick S Ward
Jun 29, 2021·Archives of Rehabilitation Research and Clinical Translation·Sarah GregorKara K Patterson
Jul 10, 2021·Developmental Science·Jarrad A G Lum, Gillian M Clark

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