PMID: 7357399Feb 3, 1980

Cerebellar tRNA methyltransferases: a developmental study

Brain Research
J Dainat, O Z Sellinger

Abstract

Developmental patterns of homologous and heterologous tRNA methylation by cerebellar tRNA methyltransferases are described. The study revealed that: (a) homologous tRNA methylation results in the predominant formation of N2-methylguanine and 1-methyladenine; (b) tRNA methyltransferase of bulk-isolated Purkinje and granule cells methylate E. coli tRNAglu2 in vitro in a characteristic manner, and (c) the methylation of 8-day-old cerebellar, cortical and hepatic tRNA in vivo yields tRNAs containing different proportions of methylated bases. The findings suggest that the presumably cell-specific populations of cerebellar tRNA methyltransferases continue to alter their substrate recognition characteristics up to and beyond the first month of post-natal life.

References

Jan 1, 1976·Biochimie·F Nau
Oct 17, 1975·Brain Research·C J CumminsO Z Sellinger
Sep 1, 1974·Journal of Neurochemistry·T C JohnsonL Chou
May 21, 1968·Biochimica Et Biophysica Acta·M Muramatsu, T Fujisawa

Related Concepts

Senility
Metazoa
Cerebellum
Cytosine
Guanine
Methylation
Purkinje Cells
TRNA Methyltransferases
Rats, Laboratory

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