Cerebellum Can Serve As a Pseudo-Reference Region in Alzheimer Disease to Detect Neuroinflammation Measured with PET Radioligand Binding to Translocator Protein

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Chul Hyoung LyooWilliam C Kreisl

Abstract

Alzheimer disease (AD) is associated with an increase in the brain of the 18-kDa translocator protein (TSPO), which is overexpressed in activated microglia and reactive astrocytes. Measuring the density of TSPO with PET typically requires absolute quantitation with arterial blood sampling, because a reference region devoid of TSPO does not exist in the brain. We sought to determine whether a simple ratio method could substitute for absolute quantitation of binding with (11)C-PBR28, a second-generation radioligand for TSPO. (11)C-PBR28 PET imaging was performed in 21 healthy controls, 11 individuals with mild cognitive impairment, and 25 AD patients. Group differences in (11)C-PBR28 binding were compared using 2 methods. The first was the gold standard method of calculating total distribution volume (V(T)), using the 2-tissue-compartment model with the arterial input function, corrected for plasma-free fraction of radiotracer (f(P)). The second method used a ratio of brain uptake in target regions to that in cerebellum-that is, standardized uptake value ratio (SUVR). Using absolute quantitation, we confirmed that TSPO binding (V(T)/f(P)) was greater in AD patients than in healthy controls in expected temporoparietal regions and ...Continue Reading

References

Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
Jan 1, 1990·Acta Neuropathologica·L A MattiaceD W Dickson
Jan 17, 2002·The New England Journal of Medicine·B A in t' VeldB H Stricker
Jun 10, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Julie C PriceChester A Mathis
Apr 5, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Marc A KrophollerAdriaan A Lammertsma
May 24, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Robert B InnisRichard E Carson
Apr 1, 2008·Pharmacology & Therapeutics·Ming-Kai Chen, Tomás R Guilarte
Dec 15, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·David R J OwenChristine A Parker
Oct 20, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·David R OwenJustin P Rubio
Apr 5, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Romina MizrahiSylvain Houle
Sep 13, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·William C KreislUNKNOWN Biomarkers Consortium PET Radioligand Project Team
Jun 19, 2013·Brain : a Journal of Neurology·William C KreislUNKNOWN Biomarkers Consortium PET Radioligand Project Team
Feb 26, 2014·Journal of Neurovirology·Jennifer M CoughlinMartin G Pomper
Mar 20, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·David R OwenEugenii A Rabiner

❮ Previous
Next ❯

Citations

Mar 18, 2016·Brain : a Journal of Neurology·Lorraine HamelinUNKNOWN Clinical IMABio3 team
Mar 18, 2016·ACS Chemical Neuroscience·Daniel Strakis AlbrechtMarco L Loggia
Jun 19, 2016·Neurobiology of Aging·William C KreislRobert B Innis
Oct 26, 2016·Annals of Neurology·Elena HerranzCaterina Mainero
Feb 10, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Daniel García-LorenzoMichel Bottlaender
Sep 16, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Talakad G LohithRobert B Innis
Nov 12, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jatta S TakkinenMerja Haaparanta-Solin
Mar 3, 2017·Annals of Neurology·Anton ForsbergLars I Eriksson
Apr 12, 2017·International Journal of Molecular Sciences·Claire TronelNicolas Arlicot
Apr 8, 2017·International Journal of Molecular Sciences·Anne-Claire DupontNicolas Arlicot
May 19, 2017·Journal of Neural Transmission·Julien LagardeMichel Bottlaender
Nov 15, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Gaia RizzoAlessandra Bertoldo
Mar 11, 2018·European Journal of Nuclear Medicine and Molecular Imaging·Zhen FanPaul Edison
Mar 7, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Arthur L BrodyMark A Mandelkern
Sep 15, 2019·Human Brain Mapping·Avinash ChandraUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Apr 3, 2020·Annals of Neurology·Nouchine HadjikhaniMichael A Moskowitz
May 30, 2019·Molecular Psychiatry·D S AlbrechtM L Loggia
Sep 26, 2020·CNS Drugs·Ayushi Anna DineshAnthony C Vernon
Aug 18, 2020·Journal of Alzheimer's Disease : JAD·Benjamin B TournierPhilippe Millet
Mar 12, 2017·Current Neurology and Neuroscience Reports·Martin Schain, William Charles Kreisl
Feb 18, 2017·Current Neurology and Neuroscience Reports·Joseph C Masdeu
Feb 8, 2019·Communications Biology·Jingshu XuRichard D Unwin
Aug 26, 2020·Cells·Benjamin B TournierPhilippe Millet
Jan 1, 2015·Clinical and Translational Imaging : Reviews in Nuclear Medicine and Molecular Imaging·Thalia F van der DoefSimon Cervenka
Dec 6, 2018·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Anna Boerwinkle, Beau M Ances
Jun 6, 2018·Journal of Alzheimer's Disease : JAD·Paul Edison, David J Brooks
Jun 27, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Nadja Van CampGilles Bonvento
Sep 11, 2019·BMC Medical Genomics·Masataka KikuchiAkihiro Nakaya
Jan 22, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Philipp BackhausJens Minnerup
Mar 14, 2020·EJNMMI Research·Eric A WoodcockAnsel T Hillmer
Feb 24, 2017·EJNMMI Research·Isadora Lopes AlvesRonald Boellaard

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Alzheimer's Disease: Neuroimaging

Neuroimaging can help identify pathological hallmarks of Alzheimer's disease (AD). Here is the latest research on neuroimaging modalities, including magnetic resonance imaging and positron emission tomography, in AD.

Alzheimer's Disease: Microglia

Microglia are a type of glial cell found throughout the brain and spinal cord. Microglia have been found to be associated with Alzheimer's disease development and progression. Here are the latest discoveries pertaining to Alzheimer's disease and microglia.

Related Papers

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Mika NaganawaYiyun Huang
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Karmen K YoderAndrew J Saykin
Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Gaia RizzoAlessandra Bertoldo
© 2021 Meta ULC. All rights reserved