Cerebral activation during hypnotically induced and imagined pain

Stuart W G DerbyshireDavid A Oakley


The continuing absence of an identifiable physical cause for disorders such as chronic low back pain, atypical facial pain, or fibromyalgia, is a source of ongoing controversy and frustration among pain physicians and researchers. Aberrant cerebral activity is widely believed to be involved in such disorders, but formal demonstration of the brain independently generating painful experiences is lacking. Here we identify brain areas directly involved in the generation of pain using hypnotic suggestion to create an experience of pain in the absence of any noxious stimulus. In contrast with imagined pain, functional magnetic resonance imaging (fMRI) revealed significant changes during this hypnotically induced (HI) pain experience within the thalamus and anterior cingulate (ACC), insula, prefrontal, and parietal cortices. These findings compare well with the activation patterns during pain from nociceptive sources and provide the first direct experimental evidence in humans linking specific neural activity with the immediate generation of a pain experience.


Jun 22, 1992·Neuroscience Letters·A V ApkarianF D Thomas
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S OgawaD W Tank
Nov 1, 1974·Psychophysiology·E R HilgardL B Sachs
Jan 1, 1995·Journal of Magnetic Resonance Imaging : JMRI·D C NollW Schneider
Oct 1, 1994·Journal of Neurology, Neurosurgery, and Psychiatry·S W DerbyshireR S Frackowiak
Jul 1, 1997·Cognition·J C MarshallR S Frackowiak
Mar 6, 1999·Pain·R D TreedeA K Jones
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·K L Casey
Sep 18, 1999·Lancet·S WesselyM Sharpe
Nov 4, 2000·Current Review of Pain·S W Derbyshire
Dec 29, 2000·Neurophysiologie clinique = Clinical neurophysiology·R PeyronL García-Larrea
Jan 12, 2002·Archives of General Psychiatry·Amir Raz, Theodore Shapiro
Jul 13, 2002·Arthritis and Rheumatism·Richard H GracelyDaniel J Clauw
Jan 1, 1962·The International Journal of Clinical and Experimental Hypnosis·R E SHOR
Mar 31, 2006·Cognitive Neuropsychiatry·D A Oakley
Jan 1, 1994·Human Brain Mapping·K J FristonA C Evans

❮ Previous
Next ❯


Dec 6, 2008·Psychopharmacology·M G Whalley, G B Brooks
Nov 15, 2011·Experimental Brain Research·Eliana ScattinaEnrica L Santarcangelo
Oct 7, 2010·European Archives of Psychiatry and Clinical Neuroscience·Stefanie KlugAigner Martin
May 17, 2007·Current Pain and Headache Reports·Stuart W G Derbyshire
Mar 1, 2012·Translational Behavioral Medicine·Tiara DillworthMark P Jensen
Oct 1, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Karolina Wartolowska, Irene Tracey
Jun 6, 2012·Proceedings of the National Academy of Sciences of the United States of America·Valeria GazzolaChristian Keysers
Feb 18, 2006·The American Journal of Clinical Hypnosis·Henriette WalterKarin Gutierrez-Lobos
Nov 13, 2008·The American Journal of Clinical Hypnosis·Mark P Jensen
Aug 15, 2009·The American Journal of Clinical Hypnosis·Jorge Cuadros, Magali Vargas
Dec 1, 2006·The International Journal of Clinical and Experimental Hypnosis·David A OakleyPeter W Halligan
Aug 30, 2008·The International Journal of Clinical and Experimental Hypnosis·Akira R O'ConnorRochelle E Cox
Nov 22, 2011·The International Journal of Clinical and Experimental Hypnosis·Jillian E AttewellRobyn Langdon
Jun 17, 2008·British Journal of Anaesthesia·I Tracey
Apr 15, 2006·BMJ : British Medical Journal·Stuart W G Derbyshire
Oct 18, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·E LangR Tröscher-Weber
Jul 7, 2005·Postgraduate Medical Journal·P J Matthews, Q Aziz
Jun 9, 2012·BMC Neuroscience·Dave J Hayes, Georg Northoff
Jun 8, 2007·Molecular Pain·Min Zhuo
Mar 6, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christopher J StarrRobert C Coghill
Feb 19, 2014·Nature Reviews. Neurology·Mark P JensenJordi Miró
Feb 3, 2005·Proceedings of the National Academy of Sciences of the United States of America·Tuukka T RaijRiitta Hari
Mar 19, 2014·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Quinton DeeleyPeter W Halligan
Sep 14, 2014·Gastrointestinal Endoscopy Clinics of North America·Salman Nusrat, Philip B Miner
Oct 13, 2014·Neurophysiologie clinique = Clinical neurophysiology·A VanhaudenhuyseM-E Faymonville
Jan 27, 2009·Journal of Orthopaedic Trauma·Owen D WilliamsonUNKNOWN Victorian Orthopaedic Trauma Outcome Registry Project Group
Jan 19, 2007·Psychotherapy and Psychosomatics·Christian H RöderDavid E J Linden
May 23, 2015·Cognitive Neuroscience·Stuart W G Derbyshire
Oct 8, 2014·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Mark P JensenShahin Hakimian
Mar 4, 2009·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Ronald KulichSteven J Scrivani
Feb 5, 2013·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Peter W Halligan, David A Oakley
Oct 3, 2012·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Giuliana MazzoniIrving Kirsch
Jul 6, 2012·Trends in Neurosciences·Carl Y Saab
Mar 15, 2012·Neuroscience Letters·Heather ChapinSean Mackey
Apr 3, 2012·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Elia ValentiniSalvatore M Aglioti
Sep 6, 2011·The Psychiatric Clinics of North America·Stuart W G Derbyshire
Jun 18, 2010·Brain Research Reviews·Eric A MoultonDavid Borsook
Mar 2, 2010·Consciousness and Cognition·David A Oakley, Peter W Halligan
May 1, 2015·The American Journal of Clinical Hypnosis·Mathieu Landry, Amir Raz
Mar 21, 2015·The American Journal of Clinical Hypnosis·Mark P JensenShahin Hakimian
May 12, 2009·Trends in Cognitive Sciences·David A Oakley, Peter W Halligan

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.