Cerebral amino acid, norepinephrine and nitric oxide metabolism in CNS oxygen toxicity

Brain Research
J ZhangC A Piantadosi

Abstract

CNS oxygen (O2) toxicity is complex, and the etiology of its most severe manifestation, O2 convulsions, is yet to be determined. A role for depletion of the brain GABA pool has been proposed, although recent data have implicated production of reactive O2 species, e.g. H2O2, in this process. We hypothesized that the production of H2O2 and NH3 produced by monoamine oxidase (MAO) would lead to depletion of GABA and production of nitric oxide (NO.) respectively, and thereby enhance CNS O2 toxicity. In this study, rats treated with an MAO inhibitor (pargyline) or a nitric oxide synthase inhibitor (LNNA) were protected against O2-induced convulsions. Selected cerebral amino acids including arginine were measured in control and O2 treated rats (6 ATA, 20 min) with or without drug pretreatment. After O2 exposure, the cerebral pools of glutamate, aspartate, and GABA decreased significantly while glutamine content increased relative to control (P < 0.05). After treatment with either enzyme inhibitor, glutamine, glutamate and aspartate concentrations were maintained near control levels. Remarkably, GABA depletion by O2 was not prevented despite protection from seizures by both pargyline and LNNA. The NO. precursor, arginine, was increased...Continue Reading

References

Oct 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·T D OuryJ D Crapo
Apr 25, 1991·European Journal of Pharmacology·L Agulló, A García
Sep 1, 1991·Journal of Applied Physiology·J Zhang, C A Piantadosi
May 1, 1991·The American Journal of Physiology·J StadlerR L Simmons
Jan 15, 1991·Biochemical Pharmacology·M B Youdim, J P Finberg
Nov 1, 1990·Journal of Applied Physiology·C A Piantadosi, L G Tatro
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D S Bredt, S H Snyder
Mar 1, 1985·Neurochemical Research·M M Zaleska, R A Floyd
Apr 1, 1968·Physiological Reviews·N Haugaard
Jan 1, 1966·Proceedings of the Society for Experimental Biology and Medicine·A P SandersB Woodhall
Aug 1, 1966·Life Sciences·J J SchildkrautI J Kopin
Oct 27, 1980·Brain Research·J A FerrendelliR A Gross
Dec 1, 1984·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·T YusaB A Freeman
Jan 1, 1982·Clinics in Chest Medicine·S G Jenkinson
Sep 1, 1963·Journal of Neurochemistry·J D WOODF M CLYDESDALE
Jan 1, 1964·The American Journal of Physiology·V POPOVICD L GILBERT

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Citations

Aug 2, 2008·European Journal of Applied Physiology·Ran ArieliAmir Abramovich
Jun 19, 1998·Brain Research·M ChavkoA L Harabin
Jul 20, 2002·Physiology & Behavior·Finn Konow Jellestad, Hilde Gundersen
Feb 15, 2001·Brain Research. Developmental Brain Research·J K PomperU Heinemann
Jan 1, 1997·Brain Research Bulletin·E DzoljicM R Dzoljic
Oct 16, 2003·Nitric Oxide : Biology and Chemistry·Mikulas ChavkoRichard M McCarron
Sep 1, 1995·DNA and Cell Biology·S M Black, P R Ortiz de Montellano
Mar 24, 2012·Journal of Applied Physiology·Ivan T DemchenkoBarry W Allen
Apr 19, 2006·Cellular and Molecular Neurobiology·Débora DelwingAngela Terezinha de Souza Wyse
Mar 26, 2005·Brain Research. Molecular Brain Research·Jinghua JinJing Zhang
Aug 2, 2003·Biochemical and Biophysical Research Communications·Guangyu GuJing Zhang
Nov 12, 2013·Journal of Internal Medicine·F Sjöberg, M Singer
Aug 26, 1998·Toxicology and Applied Pharmacology·M ChavkoA L Harabin
Jan 5, 2001·Nitric Oxide : Biology and Chemistry·I T DemchenkoC A Piantadosi
Jan 19, 2000·Nitric Oxide : Biology and Chemistry·F K GirginG Mentes
Nov 29, 2002·Circulation Research·Ivan T DemchenkoClaude A Piantadosi
Apr 10, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ivan T DemchenkoClaude A Piantadosi
Oct 11, 2008·Journal of Applied Physiology·Barry W AllenClaude A Piantadosi
Apr 6, 2000·Journal of Applied Physiology·I T DemchenkoC A Piantadosi
Apr 12, 2000·Journal of Neurophysiology·I M ElayanC R Auker
Jun 6, 1998·Journal of Applied Physiology·N Bitterman, H Bitterman

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