Cerebral amyloid angiopathy and vessel dysfunction

Cerebrovascular Diseases
S M Greenberg

Abstract

Cerebral amyloid angiopathy (CAA), defined by deposition of the beta-amyloid peptide in medium and small cortical and meningeal vessels, is a well-recognized cause of hemorrhagic stroke. This paper reviews the accumulating evidence supporting an additional role for CAA in producing vessel dysfunction, reduced cerebral blood flow and ischemia. Ischemic lesions are characteristic of several hereditary CAA syndromes, including a recently described mutation of the amyloid precursor protein associated with dementia (but not hemorrhagic stroke) in an Iowa family. Ischemic lesions are seen in some sporadic CAA patients as well, and recent data from transgenic mice suggest potential mechanisms by which beta-amyloid may alter vessel physiology. Future studies will seek to define the clinical importance of vascular beta-amyloid as a potential target for drug therapy in dementia.

Citations

Jul 10, 2003·Lancet Neurology·Michael Daffertshofer, Michael Hennerici
Oct 16, 2012·Brain : a Journal of Neurology·Adrienne DorrBojana Stefanovic
Aug 26, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Feng YuMing-Hui Zhao
Mar 3, 2005·ANZ Journal of Surgery·Jamin M MulveyPeter Spittaler
Dec 14, 2002·Annals of the New York Academy of Sciences·Youngah ShinSteven M Greenberg
Jun 24, 2004·Dementia and Geriatric Cognitive Disorders·Mattias HaglundElisabet Englund
May 13, 2006·Cerebrovascular Diseases·Luís F MaiaManuel Correia
Apr 26, 2008·Stroke; a Journal of Cerebral Circulation·Anand ViswanathanEric E Smith
Dec 10, 2008·Stroke; a Journal of Cerebral Circulation·Gregory J ZipfelJin-Moo Lee
May 1, 2006·Future Cardiology·Panayiotis G Vlachoyiannopoulos, Michael Samarkos
Apr 17, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Edward K AgyareKarunya K Kandimalla
Apr 18, 2009·Rheumatology International·Daniel AthanazioMittermayer Barreto Santiago
Oct 24, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Haifeng WuLee A Hebert
Feb 22, 2012·Insights Into Imaging·Roberto GasparottiRoberto Liserre
Feb 13, 2015·Proceedings of the National Academy of Sciences of the United States of America·Byung Hee HanGregory Joseph Zipfel
Dec 3, 2011·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Wuwei FengMagdy Selim
Jul 17, 2010·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Monzurul H ChowdhuryShuhei Yamaguchi
Apr 20, 2010·Neuropharmacology·Jinghui DongPhilip G Haydon
Aug 30, 2008·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Patrick M SullivanMark J Alberts
Sep 11, 2008·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Shen-Yang LimAndrew Evans
Mar 8, 2007·Journal of the Neurological Sciences·Luís F MaiaHoward H Feldman
Sep 22, 2010·International Journal of Stroke : Official Journal of the International Stroke Society·Yu-Wei ChenEric E Smith
Apr 15, 2006·Brain Pathology·Martin C HerzigMathias Jucker
Jun 19, 2013·The European Journal of Neuroscience·Lynsie A M ThomasonJoAnne McLaurin
Sep 4, 2009·Brain Pathology·Virawudh SoontornniyomkijHarry V Vinters
Jul 5, 2005·Neurobiology of Aging·Bozena Mazur-KoleckaJanusz Frackowiak
Sep 25, 2015·Journal of Alzheimer's Disease : JAD·Miharu SamurakiMasahito Yamada
Nov 7, 2006·International Review of Psychiatry·Michael S Rafii, Argye E Hillis
Jun 22, 2015·Current Treatment Options in Neurology·Aaron Ritter, Jagan A Pillai
Aug 24, 2016·Rheumatology·Borja Gracia-Tello, David Isenberg
Feb 2, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Rebecca J WilliamsG Bruce Pike
May 7, 2015·Stroke; a Journal of Cerebral Circulation·Ping YanJin-Moo Lee
Sep 4, 2010·Stroke; a Journal of Cerebral Circulation·Michelle L BakerUNKNOWN Multi-Centre Retinal Stroke Study Group
May 8, 2010·Stroke; a Journal of Cerebral Circulation·Keiko NishioHidekazu Tomimoto
Feb 6, 2019·Journal of the American Heart Association·Tijn M SchoutenJeroen van der Grond
Mar 1, 2006·Journal of Clinical Neurology·Raj N Kalaria, Timo Erkinjuntti
Aug 19, 2007·Journal of the American Society of Nephrology : JASN·Gary S Hill, Dominique Nochy
Jul 15, 2015·Journal of the American Society of Nephrology : JASN·Suzanne WilhelmusIngeborg M Bajema
Jun 20, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Shane M MeehanBasit Javaid

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Alzheimer's Disease: APOE

Apolipoprotein E (APOE) polymorphic alleles are major genetic risk factors for Alzheimer's disease. Discover the latest research on APOE and other genetic determinants of Alzheimer's disease here.

Related Papers

Neuropathology : Official Journal of the Japanese Society of Neuropathology
M Yamada
Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Jyoti SharmaIsha Garg
© 2022 Meta ULC. All rights reserved