Cerebral aneurysm as an exacerbating factor in stroke pathology and a therapeutic target for neuroprotection

Current Pharmaceutical Design
Naoki TajiriCesar V Borlongan

Abstract

Stroke remains a major cause of death in the US and around the world. Despite major scientific advances in our understanding of stroke pathology, the only FDA-approved drug for ischemic stroke is tissue plasminogen activator (tPA). Moreover, the therapeutic window for tPA is confined to the acute phase of stroke, thereby greatly limiting its benefits to less than 3% of ischemic stroke patients. Many treatment strategies for stroke have targeted the subacute or chronic phase in an effort to abrogate the secondary cell death that ensues after the initial stroke insult. Here, we advance the hypothesis that blood vessel disruption, or aneurysm, in the brain is an exacerbating factor for stroke, especially in the evolution of the penumbra or peri-infarct area. A better understanding of aneurysm, specifically its dynamic onset and juxtaposition to the ischemic brain tissue should facilitate the development of novel strategies for attenuating the secondary cell death associated with stroke. To this end, we discuss the laboratory and clinical evidence implicating aneurysm formation in stroke and also provide insights on how stem cell therapy may prove efficacious in combating aneurysm and stroke.

Citations

Feb 20, 2014·PloS One·Yumiko Mitome-MishimaHidenori Oishi
Apr 30, 2014·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Sangwoo RyuIn-Young Choi
Jan 1, 2014·International Scholarly Research Notices·Donald J DeGraciaZhi-Feng Huang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aneurysm

Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Related Papers

Clinical and Experimental Pharmacology & Physiology
Weiliang XiaWeihai Ying
AJNR. American Journal of Neuroradiology
F BouzeghraneInternational Consortium of Neuroendovascular Centres
Journal of Neurological Surgery. Part A, Central European Neurosurgery
Kenji YatomiHajime Arai
© 2021 Meta ULC. All rights reserved