Cerebral angiography, blood flow and vascular reactivity in progressive hypertension

NeuroImage
Yunxia LiTimothy Q Duong

Abstract

Chronic hypertension alters cerebral vascular morphology, cerebral blood flow (CBF), cerebrovascular reactivity, and increses susceptibility to neurological disorders. This study evaluated: i) the lumen diameters of major cerebral and downstream arteries using magnetic resonance angiography, ii) basal CBF, and iii) cerebrovascular reactivity to hypercapnia of multiple brain regions using arterial-spin-labeling technique in spontaneously hypertensive rats (SHR) at different stages. Comparisons were made with age-matched normotensive Wistar Kyoto (WKY) rats. In 10-week SHR, lumen diameter started to reduce, basal CBF, and hypercapnic CBF response were higher from elevated arterial blood pressure, but there was no evidence of stenosis, compared to age-matched WKY. In 20-week SHR, lumen diameter remained reduced, CBF returned toward normal from vasoconstriction, hypercapnic CBF response reversed and became smaller, but without apparent stenosis. In 40-week SHR, lumen diameter remained reduced and basal CBF further decreased, resulting in larger differences compared to WKY. There was significant stenosis in main supplying cerebral vessels. Hypercapnic CBF response further decreased, with some animals showing negative hypercapnic CBF...Continue Reading

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Citations

Mar 22, 2016·Brain Circulation·Qiang Shen, Timothy Q Duong
Aug 16, 2016·Experimental Physiology·Emma C Hart
Dec 16, 2016·Hypertension·Costantino IadecolaUNKNOWN American Heart Association Council on Hypertension; Council on Clinical Cardiology; Council on Cardiovascular Disease in the
Sep 7, 2019·Brain Sciences·Maria Jones-Muhammad, Junie P Warrington
Apr 8, 2020·Current Eye Research·Yunxia LiTimothy Q Duong
Aug 25, 2020·Psychophysiology·J Richard JenningsPeter J Gianaros
Sep 17, 2020·Translational Stroke Research·Michael S StringerJoanna M Wardlaw
Sep 8, 2017·PloS One·Anne-Sofie GrellSaema Ansar
Mar 15, 2020·American Journal of Hypertension·John Richard JenningsAlan F Sved
Jan 26, 2017·Experimental Physiology·Patrick S HosfordNephtali Marina
Jun 28, 2020·Fluids and Barriers of the CNS·Daphne M P NaessensErik N T P Bakker
Jan 1, 2021·Neurology·Maria C AdankSarah Schalekamp-Timmermans

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