Abstract
Chronic hypertension alters cerebral vascular morphology, cerebral blood flow (CBF), cerebrovascular reactivity, and increses susceptibility to neurological disorders. This study evaluated: i) the lumen diameters of major cerebral and downstream arteries using magnetic resonance angiography, ii) basal CBF, and iii) cerebrovascular reactivity to hypercapnia of multiple brain regions using arterial-spin-labeling technique in spontaneously hypertensive rats (SHR) at different stages. Comparisons were made with age-matched normotensive Wistar Kyoto (WKY) rats. In 10-week SHR, lumen diameter started to reduce, basal CBF, and hypercapnic CBF response were higher from elevated arterial blood pressure, but there was no evidence of stenosis, compared to age-matched WKY. In 20-week SHR, lumen diameter remained reduced, CBF returned toward normal from vasoconstriction, hypercapnic CBF response reversed and became smaller, but without apparent stenosis. In 40-week SHR, lumen diameter remained reduced and basal CBF further decreased, resulting in larger differences compared to WKY. There was significant stenosis in main supplying cerebral vessels. Hypercapnic CBF response further decreased, with some animals showing negative hypercapnic CBF...Continue Reading
References
Jul 1, 1977·Stroke; a Journal of Cerebral Circulation·Y Yamori, R Horie
Jan 1, 1976·Stroke; a Journal of Cerebral Circulation·Y YamoriM Fukase
Oct 1, 1992·Hypertension·L WeiJ Fenstermacher
Aug 1, 1992·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·P GohlkeT Unger
Jan 1, 1992·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J A DetreA P Koretsky
Dec 1, 1990·Hypertension·S B HarrapA F Lever
Jan 1, 1988·Circulation Research·G L BaumbachD D Heistad
Sep 1, 1980·Hypertension·M J MulvanyJ Christensen
Apr 1, 1995·Pharmacology & Therapeutics·R M Lee
Dec 1, 1993·Journal of Hypertension·M GrabowskiB B Johansson
Feb 12, 1998·Journal of Hypertension·A ZanchiD Hayoz
Nov 14, 1998·Journal of Hypertension·G HeinertD J Paterson
Sep 8, 2001·Stroke; a Journal of Cerebral Circulation·S KurodaH Abe
Feb 14, 2002·Mechanisms of Ageing and Development·Maurizio SabbatiniRoberto Avola
Feb 15, 2002·Journal of Vascular Research·Erik N T P BakkerEd VanBavel
Dec 10, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Qiang ShenTimothy Q Duong
Apr 6, 2005·NeuroImage·Kenneth M Sicard, Timothy Q Duong
Apr 27, 2005·Hypertension·Stéphane LaurentPatrick Lacolley
Jan 20, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sharon HomThomas P Davis
Jan 26, 2007·Microvascular Research·Christine' S RigsbyAnne M Dorrance
Mar 30, 2007·Brain Research·Jared F Danker, Timothy Q Duong
Jul 7, 2007·Stroke; a Journal of Cerebral Circulation·Yee Sien NgRandie M Black-Schaffer
Sep 12, 2007·The American Journal of Cardiology·Björn Dahlöf
Jul 22, 2008·The American Journal of Medicine·Laura Pedelty, Philip B Gorelick
Aug 15, 2008·Magnetic Resonance Imaging·Quan ZhouWenli Chen
Feb 28, 2009·Stroke; a Journal of Cerebral Circulation·Marilyn J CipollaJulie A Godfrey
Oct 7, 2009·Hypertension·Chang-Ki KangZang-Hee Cho
Dec 15, 2010·Experimental Neurology·Tsong-Hai LeeJr-Rung Lin
Dec 15, 2010·Stroke; a Journal of Cerebral Circulation·Randolph S Marshall, Ronald M Lazar
May 10, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Paulo W PiresAnne M Dorrance
May 24, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Eric R Muir, Timothy Q Duong
Jun 29, 2011·NeuroImage·Renata F LeoniAfonso C Silva
Oct 18, 2012·Current Hypertension Reports·Cristina SierraAntonio Coca
Nov 21, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Tae KimSeong-Gi Kim
Feb 11, 2014·NeuroImage·O SobczykJ A Fisher
Citations
Mar 22, 2016·Brain Circulation·Qiang Shen, Timothy Q Duong
Aug 16, 2016·Experimental Physiology·Emma C Hart
Sep 25, 2017·Anesthesiology·Helene BenvenisteHanbing Lu
Jul 12, 2018·Stroke; a Journal of Cerebral Circulation·Siu-Lung ChanMarilyn J Cipolla
Dec 16, 2016·Hypertension·Costantino IadecolaUNKNOWN American Heart Association Council on Hypertension; Council on Clinical Cardiology; Council on Cardiovascular Disease in the
Sep 7, 2019·Brain Sciences·Maria Jones-Muhammad, Junie P Warrington
Dec 7, 2019·GeroScience·Amani M NorlingRonald M Lazar
Apr 8, 2020·Current Eye Research·Yunxia LiTimothy Q Duong
Aug 25, 2020·Psychophysiology·J Richard JenningsPeter J Gianaros
Sep 17, 2020·Translational Stroke Research·Michael S StringerJoanna M Wardlaw
Sep 8, 2017·PloS One·Anne-Sofie GrellSaema Ansar
Jun 9, 2020·Journal of Molecular Neuroscience : MN·Yunxia LiZhiyu Nie
Mar 15, 2020·American Journal of Hypertension·John Richard JenningsAlan F Sved
Jan 26, 2017·Experimental Physiology·Patrick S HosfordNephtali Marina
Jun 28, 2020·Fluids and Barriers of the CNS·Daphne M P NaessensErik N T P Bakker
Dec 29, 2020·Brain Research·Yunxia LiTim Q Duong
Jan 29, 2019·Neuroscience·Sunil KoundalHedok Lee
Oct 9, 2021·AJNR. American Journal of Neuroradiology·L MaY Wu
Jan 1, 2021·Neurology·Maria C AdankSarah Schalekamp-Timmermans