Cerebral Arteriovenous Malformations and Epilepsy, Part 1: Predictors of Seizure Presentation

World Neurosurgery
Dale DingJason P Sheehan

Abstract

Seizures are relatively common in patients harboring cerebral arteriovenous malformations (AVMs). Because the pathogenesis of AVM-associated epilepsy is not well-defined, we aim to determine the factors associated with seizure presentation in AVM patients. We evaluated our institutional AVM radiosurgery database, from 1989-2013, to select patients in whom pertinent clinical information at presentation and adequate clinical and radiologic follow-up was available. Baseline patient demographics and AVM angioarchitectural features were compared between patients with and without seizure presentation. In addition to standard descriptive statistics, logistic regression analyses were performed to identify predictors of seizure presentation. Of the 1007 AVM patients included for analysis, 229 patients presented with seizures (22.7%). The incidence of seizure presentation was significantly higher in cortical than noncortical AVMs (33.1% vs. 6.6%, P < 0.0001). Among the cortical locations, occipital AVMs had the lowest rate of seizure presentation (21.5%, P = 0.0012), whereas the rates of seizure presentation in frontal (37.3%), temporal (37.7%), and parietal (34.0%) AVMs were similar. The lack of prior AVM hemorrhage (P < 0.0001), larger...Continue Reading

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Citations

Oct 16, 2015·World Neurosurgery·Dale DingJason P Sheehan
Aug 4, 2015·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Dale DingKenneth C Liu
Aug 11, 2015·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Dale DingR Webster Crowley
May 13, 2017·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Adeel IlyasJason P Sheehan
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Dec 2, 2017·Journal of Neurosurgery·I Jonathan PomeraniecJason P Sheehan
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May 12, 2019·Neurosurgery·Dale DingJason P Sheehan
May 16, 2017·Journal of Cerebrovascular and Endovascular Neurosurgery·Dale DingKenneth C Liu
Mar 22, 2020·Neuro-Chirurgie·Ollivier IrèneProust François
Mar 5, 2019·World Neurosurgery·Ching-Jen ChenUNKNOWN International Radiosurgery Research Foundation

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