PMID: 9551693Apr 29, 1998Paper

Cerebral aspergillosis in a liver transplant recipient: a case report of long-term survival after combined treatment with liposomal amphotericin B and surgery

Journal of Hepatology
R M IemmoloM Strazzabosco

Abstract

Cerebral aspergillosis is a life-threatening complication in liver transplant recipients, with mortality rates approaching 100%; treatment with amphotericin B is of limited efficacy because of its poor distribution in the cerebrospinal fluid and its systemic side effects. We report the case of a liver transplant recipient who developed recurrent cerebral Aspergillus fumigatus infection, and was successfully treated by combined surgical excision of the lesion and administration of liposomal amphotericin B. This first report of long-term complication-free survival in a liver transplant recipient suggests that therapy with liposomal amphotericin B may reduce the risk of recurrence of cerebral aspergillosis in these immunocompromised patients.

References

Feb 1, 1990·Mycopathologia·S M Ringel
Oct 1, 1985·Transplantation·C P WajszczukB Shaw
May 1, 1995·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J BriegelG Ruckdeschel
May 1, 1994·The Journal of Infection·R J Hay
Sep 1, 1994·The Journal of Infectious Diseases·L A CollinsA W Karchmer
Oct 1, 1993·Surgical Neurology·D G KimD H Han
Oct 1, 1995·The Journal of Antimicrobial Chemotherapy·D W Warnock

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Citations

Dec 11, 2002·Mycoses·O MolingP Mian
Jun 28, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Peter K LindenShimon Kusne
Mar 23, 2005·Intensive Care Medicine·Stephan EhrmannAnnick Legras
Mar 4, 2008·Surgical Neurology·Ratul RaychaudhuriJonathan White
Oct 29, 2014·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Francesco BarchiesiNina Singh
Aug 23, 2005·Medical Mycology·W W HopeD W Denning
Jan 29, 2000·Seminars in Pediatric Neurology·A T Pavia

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