PMID: 2502613Aug 1, 1989Paper

Cerebral blood flow and metabolism during and after prolonged hypocapnia in newborn lambs

The Journal of Pediatrics
C A GleasonM D Jones

Abstract

We studied the effects of prolonged (6 hours) hypocapnia and the abrupt termination thereof on cerebral blood flow and metabolism in six paralyzed, sedated (but not anesthetized) newborn lambs. Thirty minutes after institution of hyperventilation to an arterial carbon dioxide pressure of 15 +/- 2 torr, hyperventilation, cerebral blood flow had returned to baseline. Abrupt termination of hyperventilation after 6 hours resulted in a 110 +/- 71% increase in cerebral blood flow over baseline after 30 minutes of normocapnia. This cerebral hyperemia persisted for at least 90 minutes after hyperventilation was discontinued. Cerebral oxygen consumption did not change throughout the study. The posthypocapnia hyperemia noted in these animals after abrupt normalization of arterial carbon dioxide pressure may contribute to the increased risk of intracranial hemorrhage in newborn infants who are treated similarly in the management of pulmonary hypertension.

References

Aug 1, 1984·Pediatric Research·D CartwrightM A Heyman
Oct 1, 1963·Proceedings of the Society for Experimental Biology and Medicine·W W OPPELTD P RALL

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Citations

Nov 1, 1995·European Journal of Pediatrics·O BaenzigerH U Bucher
Mar 29, 2001·Pediatric Neurology·A PellicerF Cabañas
Feb 26, 2004·Paediatric Respiratory Reviews·Larry N Cook
Jul 5, 2002·The New England Journal of Medicine·John G Laffey, Brian P Kavanagh
Aug 1, 1995·Journal of Paediatrics and Child Health·G I LeslieJ D Arnold
May 18, 1999·Archives of Disease in Childhood. Fetal and Neonatal Edition·S KusudaT J Kim
Jan 1, 1997·Critical Care : the Official Journal of the Critical Care Forum·R PettignanoR H Clark
May 1, 1991·Brain & Development·K HashimotoS Takashima
Aug 4, 2004·The Journal of Pediatrics·Nicole S GlaserNathan Kuppermann
Jan 1, 1991·Pediatric Neurology·J Del ToroJ Goddard-Finegold
Sep 26, 2001·Clinics in Perinatology·N Ambalavanan, W A Carlo
Mar 22, 2005·Clinics in Perinatology·Marcus C Hermansen, Mary Goetz Hermansen
Jun 1, 2005·Seminars in Perinatology·Billie Lou Short
Apr 25, 2006·Pediatric Diabetes·Nicole S GlaserNathan Kuppermann
Jan 22, 2014·Pediatric Diabetes·Nicole GlaserMartha O'Donnell
Jun 7, 2005·Early Human Development·Ritsuko TakahashiAkira Onuma
Dec 18, 2001·Pediatric Pulmonology·M VarugheseJ Whitehall
Mar 17, 2010·Critical Care Medicine·Gerard CurleyJohn G Laffey
Dec 1, 1991·Journal of Speech and Hearing Research·J P Walton, K Hendricks-Munoz
Mar 21, 2006·Current Opinion in Anaesthesiology·Ozan Akça
Dec 1, 1996·Critical Care Medicine·R T Mansfield, M M Parker
Aug 12, 2006·Journal of Child Neurology·Janani Balasubramaniam, Marc R Del Bigio
Aug 18, 2004·Progress in Neurobiology·Maria ErecinskaIan A Silver
Feb 4, 2005·Journal of Clinical Ultrasound : JCU·Sumio FukudaHajime Togari

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