Cerebral blood flow and neuronal damage during progressive cerebral ischemia in gerbils

Stroke; a Journal of Cerebral Circulation
M MatsumotoT Yanagihara

Abstract

A combined autoradiographic and immunohistochemical method was used to correlate the extent of focal cerebral ischemia and morphologic ischemic damage following unilateral carotid occlusion in 16 gerbils for 5-30 minutes. Immunohistochemical lesions detectable by the reaction for microtubule-associated proteins 1 and 2 were visible in the subiculum-CA1 and CA2 regions of the hippocampus and layer III/IV of the cerebral cortex after 5 minutes of ischemia (n = 4). Local blood flow was promptly reduced but still heterogeneous after 10 minutes of ischemia (n = 4); local blood flow in immunohistochemical lesions was less than 5 ml/100 g/min except in highly vulnerable regions, where flow values of 5-15 ml/100 g/min were observed. After 15 minutes of ischemia (n = 4) local blood flow in less vulnerable regions including the thalamus and caudoputamen also declined to less than 5 ml/100 g/min, and immunohistochemical lesions became visible in those regions after 30 minutes of ischemia (n = 4). On the other hand, many brain regions tolerated local blood flow of less than 5 ml/100 g/min without ischemic damage. The present study demonstrates that selective tissue vulnerability during progressive cerebral ischemia depends on the degree of...Continue Reading

References

Jan 1, 1978·The American Journal of Physiology·O SakuradaL Sokoloff
Jan 1, 1990·Acta Neuropathologica·T YanagiharaW E Mushynski
Mar 1, 1985·Journal of Neuropathology and Experimental Neurology·T YanagiharaH A Homburger
Dec 1, 1985·Journal of Neurosurgery·T YoshimineT Yanagihara
May 1, 1984·Journal of Neurosurgery·B K Siesjö

❮ Previous
Next ❯

Citations

Nov 1, 1992·Journal of the Neurological Sciences·D M HiestandM S Kindy
Jul 25, 2003·Brain Research. Molecular Brain Research·Norihiro OhbaHiroshi Kiyama
Nov 1, 2003·The Spine Journal : Official Journal of the North American Spine Society·Lloyd W Mobley, Sandeep K Agrawal
Apr 4, 2007·Journal of Neurotrauma·Ji-Yao LiTakehiko Yanagihara
Apr 9, 2020·Frontiers in Cellular Neuroscience·Denisa Belov KirdajovaMiroslava Anderova
Mar 29, 2003·European Journal of Clinical Investigation·E BauerC Madl
Oct 13, 2020·Frontiers in Neurology·Annie G BryantRachel E Bennett
Feb 20, 2021·Journal of Neuroscience Research·Kazuo Yamagata

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carotid Artery Diseases

Carotid artery disease is a group of pathological conditions of the carotid artery. Discover the latest research on carotid artery disease here.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.