PMID: 8590549Nov 1, 1995Paper

Cerebral blood flow and resistances during hypotensive haemorrhage in the rabbit: transcranial Doppler and laser-Doppler flowmetry

Clinical Physiology
G LeftheriotisJ L Saumet

Abstract

Transcranial Doppler (TCD) determined cerebral blood flow velocity and laser Doppler flowmetry (LDF) measured cortical perfusion were simultaneously assessed during hypotensive haemorrhage in 15 anaesthetized rabbits. Systolic (Fsys), diastolic (Fdia) and mean (Fmean) blood flow velocities were recorded into the intracranial internal carotid (ICA) and basilar artery (BA). Resistance (RI = Fsys-Fdia/Fsys) and pulsatility (PI = Fsys-Fdia/Fmean) indices were calculated. Step decreases of 10 mmHg of mean arterial pressure (MAP) from 80 to less than 30 mmHg provoked a fall of LDF signal below 50 mmHg. Blood velocities decreased into BA below 40 mmHg, and below 50 mmHg into ICA indicating regional differences in cerebral autoregulation. Cortical resistances (resLDF = MAP/LDF) fell below 60 mmHg whereas RI and PI increased when MAP decreased into BA below 40 mmHg and ICA below 50 mmHg. A weak correlation was found between Fmean and LDF (BA: r = 0.55, P < 0.01 and ICA = 0.46, P < 0.01). Both RI and PI were poorly correlated to resLDF into BA (RI-resLDF: r = -0.39, P < 0.01; PI-resLDF: r = -0.39, P < 0.01) and ICA (RI-resLDF: r = -0.18, ns; PI-resLDF: r = -0.22, ns). Pulse pressure (systolic-diastolic pressure) correlated with RI (ICA: ...Continue Reading

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Citations

Aug 30, 2008·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Magdy SelimVera Novak
Oct 27, 2004·Biomedical Engineering Online·Vera NovakChung-Kang Peng
Aug 7, 2012·Journal of Basic and Clinical Physiology and Pharmacology·Breanna Willeford
Mar 11, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·T NakatouT Itoshima
Oct 24, 1998·Clinical Physiology·K Malanin, P J Kolari
Jan 28, 1998·Stroke; a Journal of Cerebral Circulation·V NovakP A Low
Sep 10, 1998·Stroke; a Journal of Cerebral Circulation·V NovakP A Low
Apr 12, 2006·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Zhi ChenPlamen Ch Ivanov
Mar 4, 1999·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·A CaronC Vigneron

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