PMID: 2492406Feb 1, 1989Paper

Cerebral blood flow does not change following sodium nitroprusside infusion during hypothermic cardiopulmonary bypass

Anesthesia and Analgesia
A T RogersL Hinshelwood

Abstract

Changes in cerebral blood flow (CBF) associated with decreases in mean arterial pressure (MAP) produced by sodium nitroprusside (SNP) infusion were measured by intra-aortic injection of 133Xe in 17 patients during hypothermic cardiopulmonary bypass (CPB). In each patient, CBF was determined at baseline and then again following SNP-induced reduction of MAP. Two groups were studied. In Group I (n = 9), PaCO2 was maintained near 42 mm Hg uncorrected for nasopharyngeal temperature (NPT). In Group II (n = 8), PaCO2 was maintained near 60 mm Hg, uncorrected for NPT. Nasopharyngeal temperature, MAP, pump oxygenator flow, PaO2, and hematocrit were maintained within a narrow range in each patient during both studies. Since the baseline CBF determinations were conducted at the higher MAP in all subjects, we corrected post-SNP CBF data for the spontaneous decline that occurs over time during CPB. In Group I, a reduction in MAP from 76 +/- 9 mm Hg (mean +/- SD) to 50 +/- 6 mm Hg was associated with a reduction in CBF from 17 +/- 5 to 13 +/- 3 ml.100 g.min-1 (P less than 0.01), a decrease that became statistically insignificant once the time correction factor had been applied (16 +/- 4 ml.100 g-1.min-1). In Group II, MAP declined from 75 +/...Continue Reading

Citations

Dec 1, 1995·The Annals of Thoracic Surgery·R E MichlerA E Schwartz
May 22, 1998·The Annals of Thoracic Surgery·N D CroughwellM F Newman
Jan 1, 1996·Journal of Cardiothoracic and Vascular Anesthesia·C O'DwyerW E Johnston
Apr 28, 2004·The Annals of Thoracic Surgery·Takahiko SakamotoRichard A Jonas
Jan 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D R SpahnB J Leone
Dec 26, 2001·Anesthesiology·Shailendra JoshiJohn Pile-Spellman
Jan 29, 2002·Anesthesia and Analgesia·Shailendra JoshiJohn Pile-Spellman

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