Cerebral blood flow in acute concussion: preliminary ASL findings from the NCAA-DoD CARE consortium

Brain Imaging and Behavior
Yang WangMichael A McCrea

Abstract

Sport-related concussion (SRC) has become a major health problem, affecting millions of athletes each year. Despite the increasing occurrence and prevalence of SRC, its underlying mechanism and recovery course have yet to be fully elucidated. The National Collegiate Athletic Association-Department of Defense Grand Alliance: Concussion Assessment, Research and Education (CARE) Consortium is a large-scale, multisite study of the natural history of concussion across multiple sports. The Advanced Research Core (ARC) of CARE is focused on the advanced biomarker assessment of a reduced subject cohort. This paper reports findings from two ARC sites to evaluate cerebral blood flow (CBF) changes in acute SRC, as measured using advanced arterial spin labeling (ASL) magnetic resonance imaging (MRI). We compared relative CBF maps assessed in 24 concussed contact sport athletes obtained at 24-48 h after injury to those of a control group of 24 matched contact sport players. Significantly less CBF was detected in several brain regions in concussed athletes, while clinical assessments also indicated clinical symptom and performance impairments in SRC patients. Correlations were found between decreased CBF in acute SRC and clinical assessments...Continue Reading

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Citations

Apr 21, 2020·Brain Imaging and Behavior·Allen A ChampagneDouglas J Cook
Aug 19, 2020·Neuropsychology Review·Yang WangLindsay D Nelson
Oct 6, 2020·Frontiers in Nutrition·Michael A RippeeMatthew K Taylor
Feb 6, 2021·Journal of Clinical Medicine·Colt A CoffmanRobert Davis Moore
Aug 25, 2021·Human Brain Mapping·Ekaterina LunkovaRajeet Singh Saluja
Aug 31, 2021·Frontiers in Neurology·Derek McAllisterMichael M Zeineh
Apr 20, 2021·American Journal of Physical Medicine & Rehabilitation·Allan Probert, Lori Grafton

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Software Mentioned

ImPACT
3dClustSim
3dCluStim
Statistical Package for Social Sciences ( SPSS
SPSS
AFNI
SPM12

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