Cerebral blood flow in bipolar disorder: A systematic review

Journal of Affective Disorders
Simina TomaBenjamin I Goldstein

Abstract

Neuroimaging of cerebral blood flow (CBF) can inform our understanding of the pathophysiology of bipolar disorder (BD) as there is increasing support for the concept that BD is in part a vascular disease. Despite numerous studies examining CBF in BD, there has not yet been a review of the literature on the topic of CBF in BD. A systematic review of the literature on CBF in BD was performed using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). Studies included measured CBF by single-photon emission computerized tomography (SPECT), positron emission tomography (PET), arterial spin labelling (ASL) or perfusion weighted imaging (PWI) in a group of BD patients. Thirty-three studies with a total of 508 subjects with BD and 538 controls were included (n = 15 SPECT; n = 8 PET; n = 7 ASL; n = 1 PWI; n = 2 other). The majority of studies in BD depression and mania reported widespread resting hypoperfusion in cingulate gyrus, frontal, and anterior temporal regions in comparison to healthy controls (HC). Findings in euthymic BD subjects and in symptomatically heterogeneous groups were less consistent. Studies that examined CBF responses to cognitive or emotional stimuli in BD subjects have reported hypoperf...Continue Reading

Citations

Dec 6, 2019·Pediatric Blood & Cancer·Michelle HanKristen W Yeom
Jun 26, 2020·Bipolar Disorders·Victor ZengMatcheri Keshavan
Jan 26, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Nicholas J LuciwBradley J MacIntosh
Feb 3, 2021·Journal of Geriatric Psychiatry and Neurology·Courtney M O'DonnellFrancisco Gonzalez-Lima
Jan 12, 2022·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·David WatsonUNKNOWN HiTOP Utility Workgroup

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