PMID: 6405647Jan 1, 1983Paper

Cerebral blood flow in children with intractable epilepsy

Brain & Development
H ShimizuJ Tanaka

Abstract

A good correlation of Doppler internal carotid blood velocity determinations with hemispheric blood flow measurements by the 133-xenon inhalation method was demonstrated in 14 epileptic patients without abnormal CT findings. The highest correlation was seen between the flow of gray matter (F1) and the internal carotid end-diastolic velocity (d) (left side r = 0.841, right side r = 0.817). As end-diastolic velocity (d) well correlated with the value obtained by the 133-xenon inhalation method, the d value was compared between 77 healthy children and 13 patients with intractable epilepsy. The mean d value of both internal carotid arteries in patients was 16.7 +/- 2.9 mm (mean +/- SD), and that of healthy children 20.9 +/- 4.3 mm, the difference being statistically significant. The low cerebral blood flow in patients might be due to multiple antiepileptic drugs administered and/or mental retardation and cerebral hypofunction related to seizures.

References

Mar 1, 1975·Stroke; a Journal of Cerebral Circulation·J RisbergJ H Halsey
May 11, 1975·Stroke; a Journal of Cerebral Circulation·W D ObristW E Wilkinson
Jan 1, 1982·Brain & Development·H ShimizuH Yabuuchi
Jan 1, 1954·The Journal of Pediatrics·J M GARFUNKELJ ZIEGLER

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Citations

Jul 1, 1989·Journal of Neurology·D DresslerK Felgenhauer
Jan 1, 1994·Neuroscience and Biobehavioral Reviews·I Jibiki, N Yamaguchi
May 1, 1992·Pediatric Neurology·Y FutagiH Yabuuchi
Aug 8, 1998·Ultrasound in Medicine & Biology·M Schöning, B Hartig

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