Cerebral blood flow is increased throughout 12 h of hypoxaemia in the mid-gestation ovine fetus

Reproduction, Fertility, and Development
G J McCrabb, R Harding

Abstract

The changes in regional cerebral blood flow (CBF) in response to prolonged hypoxaemia were measured using coloured microspheres in the 0.6-gestation ovine fetus (n = 5). Fetal hypoxaemia was induced for 12 h by reducing maternal uterine blood flow with an adjustable clamp. CBF (mL min-1 100 g-1) was increased (P < 0.05) from control values (38.7 +/- 3.5) to 105.6 +/- 5.6 at 6 h of hypoxaemia, and to 121.9 +/- 23.1 at 12 h of hypoxaemia. One hour after fetal hypoxaemia had ceased, CBF (54.0 +/- 3.3) had decreased (P < 0.05) towards control values indicating incomplete cardiovascular recovery. Cerebral vascular resistance at 6 h and 12 h of hypoxaemia was lower (P < 0.05) than control values, and returned to control values 1 h after fetal hypoxaemia had ceased. Cerebral oxygen delivery at 6 h and 12 h of hypoxaemia was not significantly different from control values, but was higher (P < 0.05) 1 h after hypoxaemia had ceased. It is concluded that CBF is sufficiently increased during prolonged hypoxaemia in the mid-gestation fetus to maintain cerebral oxygen delivery.

Citations

Jan 14, 1998·Brain Research. Developmental Brain Research·S ReesR Harding
Sep 11, 2003·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Robert Gagnon
Jun 22, 2001·Neurotoxicology and Teratology·D M SnowC F Mactutus
Oct 1, 1996·Clinical and Experimental Pharmacology & Physiology·G J McCrabb, R Harding
Oct 26, 2005·AJR. American Journal of Roentgenology·Roberto GrassiStefania Romano
Sep 24, 2004·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Diane M SnowCharles F Mactutus
Jan 31, 2006·Journal of the Society for Gynecologic Investigation·Jhodie R DuncanSandra M Rees
Nov 20, 2002·Pediatric Research·Jhodie R DuncanSandra M Rees
Aug 1, 1997·Canadian Journal of Physiology and Pharmacology·W TanD W Rurak

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