Cerebral Blood Flow, Oxygen Delivery, and Pulsatility Responses to Oxygen Inhalation at High Altitude: Highlanders vs. Lowlanders

Frontiers in Physiology
Chang-Yang XingJie Liu

Abstract

Objective: To determine whether the acute cerebral hemodynamic responses to oxygen inhalation are impacted by race or acclimation to high altitude. Methods: Three groups of young healthy males, who were Tibetans (highlanders, n = 15) with lifelong exposure to high altitude, and Han Chinese (lowlanders) with five-year (Han-5 yr, n = 15) and three-day (Han-3 d, n = 16) exposures, participated in the study at an altitude of 3658 m. Cerebral blood flow velocity (CBFV) was recorded for three minutes prior to and during pure oxygen inhalation (2 L/min), respectively, using a transcranial color-coded duplex (TCCD) sonography at the middle cerebral artery (MCA). The blood draw and simultaneous monitoring of blood pressure (BP), heart rate (HR), and finger arterial oxygen saturation (SaO2) were also performed. Results: Values are Mean ± SEM. The three groups had similar demographic characteristics and HR responses, with the group differences (P < 0.05) found in hemoglobin concentration (16.9 ± 0.9, 18.4 ± 1.3, and 15.5 ± 1.0 gm/dL), baseline BPs and HR as expected. Both the Tibetans and Han-5yr groups presented blunted BP responses to O2-inhalation when compared to the Han-3d group; more interestingly, the Tibetans showed significantly ...Continue Reading

References

Nov 1, 1977·American Journal of Physical Anthropology·I G Pawson
Sep 1, 1984·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T M MarkwalderR Aaslid
Jan 1, 1993·Journal of Applied Physiology·J ZhuangL G Moore
Aug 8, 1998·American Journal of Physical Anthropology·C M BeallC Gonzales
Jan 25, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Kirsten MøllerGitte Moos Knudsen
Jul 20, 2004·Journal of Applied Physiology·Tianyi WuZhigang Wang
Apr 30, 2005·The Journal of Physiology·L J NorcliffeR Hainsworth
Aug 3, 2005·High Altitude Medicine & Biology·Fabiola León-VelardeGustavo Zubieta-Calleja
May 15, 2007·Proceedings of the National Academy of Sciences of the United States of America·Cynthia M Beall
Jun 1, 1949·The American Journal of Physiology·H RAHN, A B OTIS
Jul 21, 2009·Experimental Physiology·Philip N Ainslie, Shigehiko Ogoh
Apr 13, 2012·The Journal of Physiology·C K WillieP N Ainslie
Nov 13, 2012·Experimental Physiology·Shigehiko OgohTadayoshi Miyamoto
Oct 25, 2013·The New England Journal of Medicine·Peter Bärtsch, Erik R Swenson
Oct 25, 2013·The New England Journal of Medicine·Buddha Basnyat
Oct 31, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jonathan D SmirlPhilip N Ainslie
Feb 25, 2014·High Altitude Medicine & Biology·Christopher ImrayUNKNOWN Birmingham Medical Research Expeditionary Society
Mar 13, 2014·Journal of Applied Physiology·Nia C S LewisPhilip N Ainslie
Mar 26, 2014·Respirology : Official Journal of the Asian Pacific Society of Respirology·Andrew O'Reilly NugentLutz Beckert
Jun 21, 2014·High Altitude Medicine & Biology·Xiaodan Yan
Nov 5, 2014·Physiology·Edward T Gilbert-KawaiDaniel S Martin
Jun 18, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Berend FeddersenHarald Ausserer
Mar 4, 2017·High Altitude Medicine & Biology·John B West

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Methods Mentioned

BETA
blood draw

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.