Cerebral blood flow, oxygen metabolism, and lactate during hypoxia in patients with obstructive sleep apnea

Sleep
M L F JensenPoul J Jennum

Abstract

Obstructive sleep apnea (OSA) is associated with increased risk of stroke but the underlying mechanism is poorly understood. We suspect that the normal cerebrovascular response to hypoxia is disturbed in patients with OSA. Global cerebral blood flow (CBF), cerebral metabolic rate of oxygen (CMRO2), and lactate concentration during hypoxia were measured in patients with OSA and matched controls. Twenty-eight patients (82.1% males, mean age 52.3 ± 10.0 years) with moderate-to-severe OSA assessed by partial polysomnography were examined and compared with 19 controls (73.7% males, mean age 51.8 ± 10.1 years). Patients and controls underwent magnetic resonance imaging (MRI) during 35 min of normoxia followed by 35 min inhaling hypoxic air (10%-12% O2). After 3 months of continuous positive airway pressure (CPAP) treatment, 22 patients were rescanned. During hypoxia, CBF significantly increased with decreasing arterial blood oxygen concentration (4.53 mL (blood)/100 g/min per -1 mmol(O2)/L, p < 0.001) in the control group, but was unchanged (0.89 mL (blood)/100 g/min per -1 mmol(O2)/L, p = 0.289) in the patient group before CPAP treatment. The CBF response to hypoxia was significantly weaker in patients than in controls (p = 0.003). ...Continue Reading

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Citations

May 10, 2020·Journal of Clinical Medicine·Régis GuieuGianfranco Parati
Dec 19, 2019·Current Sleep Medicine Reports·H Lee LauAlberto R Ramos
Jun 25, 2019·Current Treatment Options in Neurology·Melvin Parasram, Alan Z Segal
Dec 13, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Mark B VestergaardHenrik Bw Larsson
Dec 23, 2020·The Journal of Craniofacial Surgery·Bianca den OttelanderIrene Mathijssen
Sep 4, 2021·Sleep & Breathing = Schlaf & Atmung·Sofie Amalie SimonsenHelle K Iversen

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