Cerebral blood flow variability in fibromyalgia syndrome: Relationships with emotional, clinical and functional variables

PloS One
Casandra I Montoro AguilarGustavo A Reyes Del Paso

Abstract

This study analyzed variability in cerebral blood flow velocity (CBFV) and its association with emotional, clinical and functional variables and medication use in fibromyalgia syndrome (FMS). Using transcranial Doppler sonography, CBFV were bilaterally recorded in the anterior (ACA) and middle (MCA) cerebral arteries of 44 FMS patients and 31 healthy individuals during a 5-min resting period. Participants also completed questionnaires assessing pain, fatigue, insomnia, anxiety, depression and health-related quality of life (HRQoL). Fast Fourier transformation revealed a spectral profile with four components: (1) a first very low frequency (VLF) component with the highest amplitude at 0.0024 Hz; (2) a second VLF component around 0.01-to-0.025 Hz; (3) a low frequency (LF) component from 0.075-to-0.11 Hz; and (4) a high frequency (HF) component with the lowest amplitude from 0.25-to-0.35 Hz. Compared to controls, FMS patients exhibited lower LF and HF CBFV variability in the MCAs (p < .005) and right ACA (p = .03), but higher variability at the first right MCA (p = .04) and left ACA (p = .005) VLF components. Emotional, clinical and functional variables were inversely related to LF and HF CBFV variability (r≥-.24, p≤.05). However,...Continue Reading

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Citations

Feb 6, 2020·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Pablo de la CobaGustavo A Reyes Del Paso
Jul 25, 2019·Journal of Clinical Medicine·Santos VillafainaNarcís Gusi
Feb 20, 2021·Journal of Affective Disorders·Stefan DuschekCasandra I Montoro

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