Cerebral blood volume changes during brain activation.

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Steffen N KriegerRobert Turner

Abstract

Cerebral blood volume (CBV) changes significantly with brain activation, whether measured using positron emission tomography, functional magnetic resonance imaging (fMRI), or optical microscopy. If cerebral vessels are considered to be impermeable, the contents of the skull incompressible, and the skull itself inextensible, task- and hypercapnia-related changes of CBV could produce intolerable changes of intracranial pressure. Because it is becoming clear that CBV may be useful as a well-localized marker of neural activity changes, a resolution of this apparent paradox is needed. We have explored the idea that much of the change in CBV is facilitated by exchange of water between capillaries and surrounding tissue. To this end, we developed a novel hemodynamic boundary-value model and found approximate solutions using a numerical algorithm. We also constructed a macroscopic experimental model of a single capillary to provide biophysical insight. Both experiment and theory model capillary membranes as elastic and permeable. For a realistic change of input pressure, a relative pipe volume change of 21±5% was observed when using the experimental setup, compared with the value of approximately 17±1% when this quantity was calculated...Continue Reading

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Citations

May 21, 2013·Brain : a Journal of Neurology·Stefano SandroneGianvito Martino
Aug 6, 2014·Magnetic Resonance Imaging·Casey P JohnsonVincent A Magnotta
Oct 2, 2013·Sleep·Derrick J PhillipsDavid M Rector
Mar 12, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Pelin Aksit CirisRobert Todd Constable
Oct 24, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Pelin Aksit CirisR Todd Constable
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Oct 19, 2016·Journal of Biophotonics·Jinge YangHuabei Jiang
Feb 8, 2021·Journal of Neuroscience Methods·Irati MarkuerkiagaDavid G Norris
May 24, 2021·NeuroImage·Viktor PfaffenrotPeter J Koopmans

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