Sep 26, 2002

Cerebral blood volume mapping by MR imaging in the initial evaluation of brain tumors

Journal of Neuroradiology. Journal De Neuroradiologie
S KremerJ-F Le Bas

Abstract

To assess the contribution of magnetic resonance (MR) cerebral blood volume (CBV) mapping in the initial evaluation of brain tumors. 63 patients presenting a brain tumor underwent dynamic susceptibility-contrast MR imaging before surgery or biopsy: 28 high grade gliomas, 8 low grade gliomas, 2 pilocytic astrocytomas, 4 lymphomas, 12 metastases, 9 meningiomas. The CBV maps were obtained for each patient and the relative CBV (rCBV) in different areas was calculated using the ratio between the CBV in the pathological area (CBVp) and in the contralateral normal tissue(CBVn). The maximum rCBV (rCBVmax) for each tumor was determined and the mean values of rCBVmax in each group of tumors were compared using an unpaired Student t test (p=0.05). The rCBVmax for high grade gliomas (mean +/- SD: 2.6 +/- 1,2) was statistically different from low grade gliomas (0.9 +/- 0.4) (p<0.001), lymphomas (0.7 +/- 0.2) (p=0.002), meningiomas (9.1 +/- 4.4) (p<0.001) and kidney metastases (8.9 +/- 2.1) (p<0.001). The two pilocytic astrocytomas had a much lower rCBVmax than high grade gliomas. No statistically significant difference was found between high grade gliomas and lung metastases (2.4 +/- 0.9) (p=0.72). CBV mapping provides additional informatio...Continue Reading

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Mentioned in this Paper

Brain
Neoplasms
Secondary Malignant Neoplasm of Kidney
Cerebrovascular Circulation
Meningioma
Cerebral Hemisphere Structure (Body Structure)
Functional Cerebral Localization
Brain Neoplasms
Biopsy
Pathology

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