Cerebral cavernous malformation remnants after surgery: a single-center series with long-term bleeding risk analysis.

Neurosurgical Review
Marco M FontanellaFrancesco Doglietto

Abstract

The aim of this work is to investigate the long-term bleeding risk of cerebral cavernous malformation (CCM) remnants. A review of clinical, radiological, operative, and post-operative data of a cerebral cavernous malformation (CCMs) prospective database was performed. Fisher's exact test and Mann-Whitney U-test were used to assess differences between non-hemorrhagic and hemorrhagic CCM remnants for 14 variables. Recursive partitioning analysis was performed to assess the order of variables most associated with CCM remnant bleeding. Twenty-four patients out of 126 had a CCM post-surgical remnant. Of these, 7 had at least one post-operative hemorrhagic event. The mean follow-up was 80.7 months (range 12-144). CCM post-surgical remnant bleeding presented mostly with acute headache (50%) and focal neurological deficit (25%); in the remaining cases, the hemorrhage was asymptomatic. Retreatment was performed in two patients, with surgery and radiosurgery, respectively; no treatment was performed in the majority of cases. All patients ranked as non-II, according to Zabramski classification, did not show any post-surgical bleeding. The presence of a pre-operative perilesional hemosiderin ring was highly significant in predicting post-s...Continue Reading

References

Nov 11, 1991·Journal of Neurosurgery·O Del CurlingT E Craven
Nov 1, 1991·Journal of Neurosurgery·J R RobinsonJ R Little
Jul 1, 1995·Journal of Neurosurgery·T AibaT Komata
Mar 1, 1994·Journal of Neurosurgery·J M ZabramskiG Brown
Apr 8, 2006·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·P FerroliG Broggi
Nov 1, 2008·Stroke; a Journal of Cerebral Circulation·Rustam Al-Shahi SalmanUNKNOWN Angioma Alliance Scientific Advisory Board
Nov 27, 2010·Swiss Medical Weekly·Oliver BozinovHelmut Bertalanffy
Apr 10, 2012·World Neurosurgery·Bradley A GrossRose Du
Apr 28, 2012·Neurosurgical Focus·Marco CenzatoPietro Versari
Jun 29, 2012·Acta neurochirurgica·Maria WostrackMichael Stoffel
Jan 30, 2015·TheScientificWorldJournal·Nikolaos MouchtourisPascal M Jabbour
Aug 15, 2015·AJNR. American Journal of Neuroradiology·O NikoubashmanM Wiesmann
Mar 21, 2017·Cerebrovascular Diseases·Antonio ArauzEdgar Nathal
May 16, 2017·Journal of Cerebrovascular and Endovascular Neurosurgery·Dale DingKenneth C Liu

❮ Previous
Next ❯

Citations

Jun 30, 2021·Journal of Neurosurgical Sciences·Marco M FontanellaDaniele Rigamonti

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.